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Chitosan for gene delivery: Methods for improvement and applications.

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机构： [a]State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery,West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China [b]Department of Urology, Institute of Urology,West China Hospital, Sichuan University, Chengdu 610041, PR China

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关键词： Gene therapy Gene delivery Non-viral vector Chitosan Polysaccharide

摘要：

Gene therapy is a promising strategy for treating challenging diseases. The successful delivery of genes is a critical step for gene therapy. However, concerns about immunogenicity and toxicity are the main obstacles against the widespread use of effective viral systems. Therefore, nonviral vectors are regarded as good alternatives to viral vectors. Chitosan is a natural cationic polysaccharide that could be used to create nonviral gene delivery vectors. Various methods have been developed to improve the properties of chitosan related to gene delivery. This review introduces the features of chitosan in gene delivery, summarizes current progress toward methods promoting the properties of chitosan related to gene delivery, and presents different applications of chitosan in gene delivery vectors. Finally, future prospects of gene vectors based on chitosan are discussed. Copyright © 2019 Elsevier B.V. All rights reserved.

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出版当年[2019]版中科院分区表Review为是的期刊

：

大类 | 2 区化学

小类 | 2 区物理化学

最新[2023]版

：

大类 | 1 区

化学

小类 | 1 区物理化学

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第一作者机构： [a]State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery,West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China

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