详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Neurosurgery, Liaocheng City Hospital of Traditional Chinese Medicine, Liaocheng,252000, Shandong, P.R. China [2]Department of Urinary Surgery, Jinan Third People's Hospital, Jinan, Shandong 250101, P.R. China [3]Department of Dermatology , First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China [4]Department of Gastroenterology, Lincang People's Hospital, Lincang, China [5]School of Public Health, Benedictine University, Lisle, United States [6]Department of General Surgery, Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, 518055, China [7]International Association for Diagnosis and Treatment of Cancer, Shenzhen, Guangdong 518055, China [8]Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China [9]Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250000, China [10]Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150, Australia [11]Department of Biomedical Engineering, Erciyes University, Kayseri 38039, Türkiye [12]ERNAM –Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye [13]UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye [14]Department of Oncology, Suining Central Hospital, Suining City, Sichuan, China

出处：

DOI：

ISSN：

关键词： Chitosan nanoparticles hyaluronic acid nanoparticles phototherapy chemotherapy immunotherapy

摘要：

Cancer phototherapy has introduced a new potential modality for tumor suppression. However, the efficacy of phototherapy has been limited due to a lack of targeted delivery of photosensitizers. Therefore, the application of biocompatible and multifunctional nanoparticles in phototherapy is appreciated. Chitosan (CS) as a cationic polymer and hyaluronic acid (HA) as a CD44-targeting agent are two widely utilized polymers in nanoparticle synthesis and functionalization. The current review focuses on the application of HA and CS nanostructures in cancer phototherapy. These nanocarriers can be used in phototherapy to induce hyperthermia and singlet oxygen generation for tumor ablation. CS and HA can be used for the synthesis of nanostructures, or they can functionalize other kinds of nanostructures used for phototherapy, such as gold nanorods. The HA and CS nanostructures can combine chemotherapy or immunotherapy with phototherapy to augment tumor suppression. Moreover, the CS nanostructures can be functionalized with HA for specific cancer phototherapy. The CS and HA nanostructures promote the cellular uptake of genes and photosensitizers to facilitate gene therapy and phototherapy. Such nanostructures specifically stimulate phototherapy at the tumor site, with particle toxic impacts on normal cells. Moreover, CS and HA nanostructures demonstrate high biocompatibility for further clinical applications.Copyright © 2024. Published by Elsevier B.V.

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区高分子科学 2 区生化与分子生物学

最新[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区高分子科学 2 区生化与分子生物学

第一作者：

第一作者机构： [1]Department of Neurosurgery, Liaocheng City Hospital of Traditional Chinese Medicine, Liaocheng,252000, Shandong, P.R. China

共同第一作者：

通讯作者：

通讯机构： [6]Department of General Surgery, Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, 518055, China [7]International Association for Diagnosis and Treatment of Cancer, Shenzhen, Guangdong 518055, China [8]Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China [9]Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250000, China [11]Department of Biomedical Engineering, Erciyes University, Kayseri 38039, Türkiye [12]ERNAM –Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye [13]UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye

推荐引用方式(GB/T 7714)：

APA：

MLA：

Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy

文献详情

相关文献