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Biomembrane-wrapped gene delivery nanoparticles for cancer therapy

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机构： [1]Department of Geriatrics, Chengdu Fifth People's Hospital, Geriatric Diseases Institute of Chengdu, Chengdu, Sichuan, China. [2]Center for Medicine Research and Translation, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China. [3]Chengdu Ping An Healthcare Medical Examination Laboratory, Chengdu, Sichuan, China. [4]College of Clinical Medical, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. [5]Department of Pathophysiology, Shenzhen University Health Science Center, Shenzhen, Guangdong, China.

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关键词： gene delivery membrane-wrapped biomimetic nanovectors advantages and obstacles tumor targeting efficacy improvement strategies

摘要：

As a promising strategy, gene delivery for cancer treatment accepts encouraging progress due to its high efficacy, low toxicity, and exclusive selectivity. However, the delivery efficiency, specific biological distribution, targeted uptake, and biosafety of naked nucleic acid agents still face serious challenges, which limit further clinical application. To overcome the above bottleneck, safe and efficient functional nanovectors are developed to improve the delivery efficiency of nucleic acid agents. In recent years, emerging membrane-wrapped biomimetic nanoparticles (MBNPs) based on the concept of "imitating nature" are well known for their advantages, such as low immunogenicity and long cycle time, and especially play a crucial role in improving the overall efficiency of gene delivery and reducing adverse reactions. Therefore, combining MBNPs and gene delivery is an effective strategy to enhance tumor treatment efficiency. This review presents the mechanism of gene therapy and the current obstacles to gene delivery. Remarkably, the latest development of gene delivery MBNPs and the strategies to overcome these obstacles are summarized. Finally, the future challenges and prospects of gene delivery MBNPs toward clinical transformation are introduced. The principal purpose of this review is to discuss the biomedical potential of gene delivery MBNPs for cancer therapy and to provide guidance for further enhancing the efficiency of tumor gene therapy.Copyright © 2023 Li, Zeng, Li, Song and Dong.

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出版当年[2023]版：

大类 | 3 区工程技术

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 3 区工程技术

小类 | 3 区综合性期刊

第一作者：

第一作者机构： [1]Department of Geriatrics, Chengdu Fifth People's Hospital, Geriatric Diseases Institute of Chengdu, Chengdu, Sichuan, China. [2]Center for Medicine Research and Translation, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.

通讯作者：

通讯机构： [1]Department of Geriatrics, Chengdu Fifth People's Hospital, Geriatric Diseases Institute of Chengdu, Chengdu, Sichuan, China. [2]Center for Medicine Research and Translation, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.

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