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Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer(Open Access)

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收录情况： ◇ SCIE ◇ 卓越：高起点新刊

作者：
Nie, W[a,b] ; Yu, T[c] ; Liu, X[d] ; Wang, B[e] ; Li, T[a] ; Wu, Y[a] ; Zhou, X[a] ; Ma, L[a] ; Lin, Y[f,g] ; Qian, Z[a] ; Gao, X[a] ;
机构： [a]Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China [b]Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China [c]Department of Pathology and Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, China [d]Department of Radiation Oncology, Cancer Center, Affiliated Hospital of Xuzhou Medical University, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, 221000, China [e]Department of Pharmacy, West China Second University Hospital of Sichuan University, Chengdu, 610041, China [f]State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China [g]College of Biomedical Engineering, Sichuan University, Chengdu, 610041, China
出处：
DOI： 10.1016/j.bioactmat.2021.03.031
ISSN：

关键词： Cancer CKb11 Immunogene therapy Macrophages polarization Nanocomposites

摘要：
The immunosuppressive tumor microenvironment (TME) of cancer strongly hinders the anti-tumor immune responses, thereby resulting in disappointing responses to immunotherapy. Chemoattractive and promotive traits of chemokines exerted on leukocytes have garnered interest in improving the efficiency of immunotherapy by increasing the infiltration of immune cells in the TME. In this study, a folic acid (FA) -modified gene delivery system based on the self-assembly of DOTAP, MPEG-PCL-MPEG, and FA-PEG-PCL-PEG-FA, namely F-PPPD, was developed to deliver plasmids encoding the immunostimulating chemokine CKb11. The delivery of plasmid CKb11 (pCKb11) by F-PPPD nanoparticles resulted in the high secretion of CKb11 from tumor cells, which successfully activated T cells, suppressed the M2 polarization of macrophages, promoted the maturation of dendritic cells (DCs), facilitated the infiltration of natural killer (NK) cells and inhibited the infiltration of immunosuppressive cells in tumor tissues. Administration of F-PPPD/pCKb11 also significantly suppressed the cancer progression. Our study demonstrated a nanotechnology-enabled delivery of pCKb11, that remodeled the immunosuppressive TME, for cancer treatment. © 2021 The Authors

基金：
This work was supported by the Ministry of Science and Technology of the People’s Republic of China (No. 2018ZX09201018). This work was supported by Sichuan Science and Technology Program (No. 2019YFS0089, 2019YFS0340 and 2020YFS0217). This work was supported by the China Postdoctoral Science Foundation (No. 2020M680150) and full-time postdoctoral research and development fund of Sichuan University (No. 20826041D4048). This work was supported by the full-time postdoctoral research and development fund of West China Hospital of Sichuan University (No. 2020HXBH059 and No. 2020HXBH002), 1⋅3⋅5 project of excellent development of discipline of West China Hospital of Sichuan University (No. ZYYC21005), and the Natural Science Foundation Youth Project of Jiangsu Province (BK20190989).
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外文
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出版当年[2021]版：
大类 | 1 区 材料科学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2021]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [a]Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China [b]Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Nie W,Yu T,Liu X,et al.Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer(Open Access)[J].BIOACTIVE MATERIALS.2021,6(11):3678-3691.doi:10.1016/j.bioactmat.2021.03.031.
APA：
Nie, W,Yu, T,Liu, X,Wang, B,Li, T...&Gao, X.(2021).Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer(Open Access).BIOACTIVE MATERIALS,6,(11)
MLA：
Nie, W,et al."Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer(Open Access)".BIOACTIVE MATERIALS 6..11(2021):3678-3691

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