机构：[1]Sichuan Provincial Key Laboratory for Human Disease Gene Study, The Institute of Laboratory Medicine, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of China四川省人民医院[2]Department of Clinical Laboratory, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China四川省人民医院四川省肿瘤医院[3]College of Clinical Medicine, Southwest Medical University, Luzhou, People’s Republic of China[4]Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, People’s Republic of China四川省人民医院[5]School of Medicine, University of Electronic Science and Technology of China Sichuan, Chengdu, People’s Republic of China四川省人民医院
Recently, several human genetic and genomewide association studies (GWAS) have discovered many genetic loci that are associated with the concentration of the blood lipids. To confirm the reported loci in Chinese population, we conducted a cross-section study to analyse the association of 25 reported SNPs, genotyped by the ABI SNaPshot method, with the blood levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) in 1900 individuals by multivariate analysis. Logistic regression was applied to assess the association of the genetic loci with the risk of different types of dyslipidemia. Our study has convincingly identified that 12 of 25 studied SNPs were strongly associated with one or more blood lipid parameters (TC, LDL, HDL and TG). Among the 12 associated SNPs, 10 significantly influence the risk of one or more types of dyslipidemia. We firstly found four SNPs (rs12654264 in HMGCR; rs2479409 in PCSK9; rs16996148 in CILP2, PBX4; rs4420638 in APOE-C1-C4-C2) robustly and independently associate with four types of dyslipidemia (MHL, mixed hyperlipidemia; IHTC, isolated hypercholesterolemia; ILH, isolated low HDL-C; IHTG, isolated hypertriglyceridemia). Our results suggest that genetic susceptibility is different on the same candidate locus for the different populations. Meanwhile, most of the reported genetic variants strongly influence one or more plasma lipid levels and the risk of dyslipidemia in Chinese population.
第一作者机构：[1]Sichuan Provincial Key Laboratory for Human Disease Gene Study, The Institute of Laboratory Medicine, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of China[2]Department of Clinical Laboratory, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Sichuan Provincial Key Laboratory for Human Disease Gene Study, The Institute of Laboratory Medicine, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of China[3]College of Clinical Medicine, Southwest Medical University, Luzhou, People’s Republic of China[4]Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, People’s Republic of China[5]School of Medicine, University of Electronic Science and Technology of China Sichuan, Chengdu, People’s Republic of China
推荐引用方式(GB/T 7714)：
HUAICHAO LUO,XUEPING ZHANG,PING SHUAI,et al.Genetic variants influencing lipid levels and risk of dyslipidemia in Chinese population[J].JOURNAL OF GENETICS.2017,96(6):985-992.doi:10.1007/s12041-017-0864-x.
APA：
HUAICHAO LUO,XUEPING ZHANG,PING SHUAI,YUANYING MIAO,ZIMENG YE&YING LIN.(2017).Genetic variants influencing lipid levels and risk of dyslipidemia in Chinese population.JOURNAL OF GENETICS,96,(6)
MLA：
HUAICHAO LUO,et al."Genetic variants influencing lipid levels and risk of dyslipidemia in Chinese population".JOURNAL OF GENETICS 96..6(2017):985-992
