机构：[1]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China[2]Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China[3]Department of Anatomy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China[4]Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, People’s Republic of China[5]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People’s Republic of China[6]Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People’s Republic of China
The programmed cell death 6 (PDCD6), discovered as a proapoptotic calcium-binding protein, has recently been found dysregulated in tumors of various origin and contributed to cancer cell viability. The aim of this study was to determine whether SNPs in PDCD6 are associated with cervical squamous cell carcinoma (CSCC). Polymerase chain reaction-restriction fragment length polymorphism method was used to genotype two tag SNPs (rs3756712 and rs4957014) of PDCD6 in 328 CSCC patients and 541 controls. Significantly increased CSCC risks were found to be associated with T allele of rs3756712 and G allele of rs4957014 (P = 0.017, OR = 1.320, and P = 0.007, OR = 1.321, respectively). CSCC risks were associated with these two SNPs in different genetic model (P = 0.04, OR = 1.78 for rs3756712 in a recessive model, and P = 0.006, OR = 2.01 for rs4957014 in a codominant model, respectively). Results of stratified analyses revealed that rs4957014 is associated with parametrial invasion of CSCC (P = 0.044, OR = 1.414). Our results suggest that these two tag SNPs of PDCD6 are associated with CSCC, indicating that PDCD6 may play an important role in the pathogenesis of CSCC.
基金：
This work was supported by the National Natural
Science Foundation of China (No. 81172440, No. 81272821, No.
81172494 and No. 30901596); the Applied Basic Research Programs
of Science and Technology Commission Foundation of Sichuan
Province (No. 2013JY0008 and No. 2013JY0013); and Program for
Changjiang Scholars and Innovative Research Team in University
(PCSIRT0935).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区遗传学4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区遗传学4 区肿瘤学
第一作者：
第一作者机构：[1]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Bin Zhou,Peng Bai,Hui Xue,et al.Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma.[J].Familial cancer.2015,14(1):1-8.doi:10.1007/s10689-014-9767-7.
APA：
Bin Zhou,Peng Bai,Hui Xue,Zhu Zhang,Shaoqing Shi...&Lin Zhang.(2015).Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma..Familial cancer,14,(1)
MLA：
Bin Zhou,et al."Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma.".Familial cancer 14..1(2015):1-8
