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Interleukin-31 single nucleotide polymorphisms are significantly associated with endometrial cancer in Chinese Han women.

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机构： [1]Departments of Obstetrics and Gynecology,West China Second Hospital, Sichuan University, Number 20, 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China [2]Departments of Pathology, West China Second Hospital, Sichuan University, Number 20, 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan Province, China [4]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China [5]Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China [6]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province, China.

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At present, cancer genetic markers of susceptibility (CGEMS) are a very important cancer research topic. This study aims to investigate possible correlations between the emergence of endometrial cancer (EC) and the presence of polymorphisms in two gene sites (rs4758680 and rs7977932) of interleukin-31 (IL-31) in a well-defined Chinese cohort. Polymerase Chain-Reaction (PCR) was performed to determine the genotypic composition and the allelic frequencies of IL-31 gene variants in 255 EC patients and 370 healthy controls. Our results revealed a statistically significant association between the presence of allele A of rs4758680 and increased EC risk (P = 0.009). Moreover, genotypic frequencies in the codominant (P = 0.0041), dominant (P = 0.0018), and overdominant (P<0.001) genetic models of rs4758680 were associated with EC susceptibility. For rs7977932, allele G was statistically more frequent in EC patients (P = 0.043). Our findings suggest that polymorphisms in rs4758680 and rs7977932 of IL-31 may have a role in increased susceptibility to EC in Chinese Han women. IJCEP Copyright © 2018.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

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第一作者：

第一作者机构： [1]Departments of Obstetrics and Gynecology,West China Second Hospital, Sichuan University, Number 20, 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan Province, China

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通讯机构： [1]Departments of Obstetrics and Gynecology,West China Second Hospital, Sichuan University, Number 20, 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan Province, China [4]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China [6]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province, China. [*1]Department of Obstetrics and Gynecology, West China Second University Hospital, No. 20 Block 3, Renminnan Road, Chengdu 610041, Sichuan Province, China [*2]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan Province, China.

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