详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Single nucleotide polymorphisms within NFKBIA are associated with nasopharyngeal carcinoma susceptibility in Chinese Han population

106| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [a]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of [b]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China [c]Sichuan Provincial Key Laboratory for Disease Gene Study and Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial [d]Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Chengdu, China [e]Department of Radiological Protection, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China

出处：

DOI：

ISSN：

关键词： Nasopharyngeal carcinoma NFKBIA Single nucleotide polymorphisms Susceptibility

摘要：

Genes involved in latent membrane protein 1 (LMP1) signaling pathways have been suggested to play an important role in nasopharyngeal carcinogenesis. We investigated potentially functional genetic variants associated with the risk of nasopharyngeal carcinoma (NPC) in genes involved in the LMP1 signaling pathway. Altogether, 73 single nucleotide polymorphisms (SNPs) with MAF ≥ 10% were located within the regions of interest of the four genes TRAF3, NFKBIA, CHUK and MAP2K4. From these, 10 SNPs were selected for genotyping based on LD (r2 ≥ 0.80) in a hospital-based case-control study of 332 NPC cases and 585 healthy controls from the Chinese Han population. Minor allele carriers of the promoter SNP rs2233409 in NFKBIA, had an increased risk of NPC (AA vs GG: OR 7.14, 95%CI, 1.08–34.18, P = 0.04, dominant model). Based on the results, we concluded that rs2233409 polymorphism in NFKBIA may be moderately associated with the risk of NPC. Further studies with larger independent samples and functional analysis are needed to verify our results. © 2020 Elsevier Ltd

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区细胞生物学 3 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区细胞生物学 3 区免疫学

JCR分区：

出版当年[2021]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY Q3 IMMUNOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY Q2 IMMUNOLOGY

影响因子： 3.7 最新[2023版] 3.5 最新五年平均 3.926 出版当年[2021版] 4.033 出版当年五年平均 3.861 出版前一年[2020版] 3.8 出版后一年[2022版]

第一作者：

第一作者机构： [a]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of

共同第一作者：

通讯作者：

通讯机构： [a]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of [e]Department of Radiological Protection, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China [*1]Renmin South Rd 55#, 610041 Chengdu, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Single nucleotide polymorphisms within NFKBIA are associated with nasopharyngeal carcinoma susceptibility in Chinese Han population

文献详情

相关文献