机构：[1]Sichuan Univ, West China Hosp, Dept Urol, Inst Urol, Chengdu, Sichuan, Peoples R China[2]Sichuan Univ, West China Hosp, Dept Vasc Surg, Chengdu, Sichuan, Peoples R China[3]Sichuan Univ, West China Hosp, Dept Liver Surg, Chengdu, Sichuan, Peoples R China[4]Sichuan Univ, West China Hosp, Dept Oncol, Chengdu, Sichuan, Peoples R China[5]Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Sichuan, Peoples R China[6]Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Sichuan, Peoples R China
Background: Prostate cancer is one of the most common cancers in men. LIM kinase1 (LIMK1) is a mediator in the process of cytoskeleton reorganization and cell motility. LIMK1 is related to progression, invasiveness and metastases of prostate cancer. However, the relationship between LIMK1 single nucleotide polymorphism (SNP) and the risk of prostate cancer has not been studied. Aim: The aim of our study is to determine the association between LIMK1 polymorphisms and the risk of prostate in a Chinese population. Methods: This case-control study consisted of 162 prostate cancer patients and 187 healthy control subjects. Five SNPs of LIMK1 including rs2269082, rs2269081, rs178409, rs6460071 and rs710968 were genotyped using iPLEX genotyping assays on a MassARRAY((R)) platform. Results: No significant relationships were found between polymorphisms genotypes and the risk of prostate cancer. Also, no significant associations were found between genotypes and the individual factors such as Gleason Score, alcohol and cigarette consuming statuses. Conclusion: These polymorphisms of LIMK1 were not significantly associated with prostate cancer susceptibility in Chinese men.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81370272, 30901621/C1705]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Sichuan Univ, West China Hosp, Dept Urol, Inst Urol, Chengdu, Sichuan, Peoples R China
通讯作者：
通讯机构：[5]Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Sichuan, Peoples R China[6]Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Sichuan, Peoples R China
推荐引用方式(GB/T 7714)：
Wei Wuran,Zeng Guojun,Liu Chang,et al.Associations of LIM kinase1 (LIMK1) gene single nucleotide polymorphisms with prostate cancer susceptibility in Chinese population[J].International journal of clinical and experimental pathology.2017,10(9):9725-9734.
APA：
Wei, Wuran,Zeng, Guojun,Liu, Chang,Zou, Bingwen&Li, Li.(2017).Associations of LIM kinase1 (LIMK1) gene single nucleotide polymorphisms with prostate cancer susceptibility in Chinese population.International journal of clinical and experimental pathology,10,(9)
MLA：
Wei, Wuran,et al."Associations of LIM kinase1 (LIMK1) gene single nucleotide polymorphisms with prostate cancer susceptibility in Chinese population".International journal of clinical and experimental pathology 10..9(2017):9725-9734
