机构：[1]Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China[2]Department of Radiology, Peking Union Medical College Hospital, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China四川大学华西医院[3]West China School of Medicine, Sichuan University, Chengdu, Sichuan, China四川大学华西医院[4]Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[5]The Periodical Press of West China Hospital, Sichuan University, Chengdu, Sichuan, China四川大学华西医院[6]West China Hospital, Sichuan University, Chengdu, Sichuan, China四川大学华西医院
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated before. This study investigated the associations between three polymorphisms (rs1130214, rs3730358, and rs2494732) in AKT1 and the risk of development of prostate cancer in the Chinese Han population. Sequenom MassARRAY & iPLEX technology were used to genotype these polymorphisms in 493 Chinese Han patients with prostate cancer and 309 age-matched healthy individuals. Compared to the CC genotype of the rs3730358 polymorphism, the CT genotype of the same polymorphism was strongly associated with a decreased risk of prostate cancer (OR = 0.617, 95%CI = 0.390-0.976, P = 0.037). However, there was no significant difference between the allele frequency of the rs3730358 polymorphism and those of the other two polymorphisms (P > 0.05). Moreover, no significant difference was found in the haplotype analysis (P > 0.05). Our study found that the variant genotype CT of rs3730358 of AKT1 was associated with a decreased risk of prostate cancer, which suggested that this polymorphism could play an important role in the development of the disease.
基金：
Research supported by Grant #2014K158 from the Administration of Traditional
Chinese Medicine of Sichuan Province (J.M. Liu), Grant #2014SZ0031 from the Science and
Technology Administration of Sichuan Province (J.M. Liu), Grant #31170907 (K.J. Wang),
#31370951 (K.J. Wang), #81470927 (K.J. Wang), and #81300579 (K.J. Wang) from the
National Natural Science Foundation of China, Grant #2014SCU04B21 (K.J. Wang) from Fund
for Distinguished Young Scholars of Sichuan University, Grant #JH2014053 (K.J. Wang) from
the Academic Leader Training Fund of the Sichuan Province, and Grant #JH2015017 (K.J.
Wang) from the Application-Oriented Foundation of Committee Organization Department of
the Sichuan Provincial Party.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu J M,Cheng S H,Xia C,et al.Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.[J].Genetics and molecular research : GMR.2017,16(1):doi:10.4238/gmr16019469.
APA：
Liu J M,Cheng S H,Xia C,Deng T,Zhu Y C...&Li H.(2017).Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population..Genetics and molecular research : GMR,16,(1)
MLA：
Liu J M,et al."Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.".Genetics and molecular research : GMR 16..1(2017)
