机构：[1]Department of Dermatology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.四川省人民医院[2]Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba 279-0021, Japan.[3]Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.[4]Department of Pathology, Air Force Hospital of Western Theater Command, Chengdu 610065, China.[5]Sichuan Provincial Key Laboratory for Genetic Disease, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.四川省人民医院
Background/Objective: Cutaneous melanoma is a highly heterogeneous malignancy and life-threatening skin cancer with rising global incidence. Although various therapeutic options are available, their clinical efficacy remains limited, highlighting the urgent need for novel strategies that facilitate prevention, diagnosis, and treatment. The aim of this study was to explore the potential causal association between medication use and the risk of developing cutaneous melanomas. Methods: Using summary data from Genome-Wide Association Studies (GWASs), we performed Mendelian randomization (MR) to investigate the causal effect of medication use on cutaneous melanoma risk. Exposure data were based on self-reported medication uses from ~320,000 European participants in the UK Biobank. The outcomes included GWAS results from 2824 cutaneous melanoma cases. Single-nucleotide polymorphisms (SNPs) significantly associated with medication use were used as instruments and analyzed with IVW, weighted median, weighted mode, and MR-Egger methods. Sensitivity analyses were used to assess pleiotropy and heterogeneity. Results: The analysis revealed that genetically predicted high use of adrenergics, inhalers, glucocorticoids, and opioids was suggestively associated with a reduced risk of cutaneous melanoma. Sensitivity analyses supported the robustness of these findings, showing no evidence of horizontal pleiotropy or influence from outliers. Conclusions: The results presented herein suggest that certain medication uses may lower the risk of developing cutaneous melanomas, offering potential new avenues for future prevention and treatment strategies.
基金：
This research was funded by grants from Chengdu Municipal Health Commission (2024025)
and the Key Research and Development Project of Sichuan Provincial Science and Technology
Department (2023YFS0311; 2022YFS0310).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
最新[2025]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
JCR分区：
出版当年[2024]版：
Q1PHARMACOLOGY & PHARMACYQ2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q1PHARMACOLOGY & PHARMACYQ2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Dermatology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wan Huiying,Zhong Ling,Su Jia,et al.Potential Risk of Cutaneous Melanoma Attributable to Medication Use: A Mendelian Randomization Approach[J].Biomedicines.2025,13(10):doi:10.3390/biomedicines13102477.
APA：
Wan Huiying,Zhong Ling,Su Jia,Zhao Qiaofeng,Tominaga Mitsutoshi...&Zhang Dingding.(2025).Potential Risk of Cutaneous Melanoma Attributable to Medication Use: A Mendelian Randomization Approach.Biomedicines,13,(10)
MLA：
Wan Huiying,et al."Potential Risk of Cutaneous Melanoma Attributable to Medication Use: A Mendelian Randomization Approach".Biomedicines 13..10(2025)
