机构：[1]Department of Nutrition,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China[2]Department of Epidemiology,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China[3]Cancer Center of the First Hospital of Jilin University,Changchun 130021,Jilin China[4]Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China[5]Department of Medical Oncology,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital,Fuzhou 350014,Fujian,China[6]Department of Gastrointestinal Surgery,Affliated Tumor Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China[7]Department of Surgery,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong,China中山大学附属第一医院[8]Department of Clinical Nutrition,West China Hospital of Sichuan University,Chengdu 610041,Sichuan,China四川大学华西医院[9]Department of Gastrointestinal Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China[10]Department of Nutrition and Metabolism of Oncology,The First Affiliated Hospital of University of Science and Technology of China,Anhui Provincial Cancer Hospital,Hefei 230031,Anhui,China[11]Department of Clinical Nutrition,The First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei,China[12]Department of Gastrointestinal Surgery,Institute of Gastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China昆明医科大学附属第一医院[13]Department of Clinical Nutrition,The First Affiliated Hospital of Zhejiang Chinese Medical University,Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310006,Zhejiang,China[14]Department of Clinical Nutrition,Chongqing General Hospital,Chongqing 400014,China[15]Department of Colorectal and Anal Surgery,Huizhou Municipal Central Hospital,Huizhou 516001,Guangdong,China[16]Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China[17]Department of Oncology,Xingtai People's Hospital,Hebei Medical University,Xingtai 054031,Hebei,China[18]Harbin Medical University Cancer Hospital,Harbin 150085,Heilongjiang,China[19]Department of Nutrition,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong,China广东省人民医院[20]Department of Oncology,Affliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital,Zhengzhou 450008,Henan,China河南省肿瘤医院[21]Department of General Surgery,Xiangya Hospital,Central South University,Changsha 410008,Hunan,China[22]Comprehensive Oncology Department,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China[23]Department of Oncology,the Second Affiliated Hospital of Zunyi Medical University,Zunyi 563006,Guizhou,China[24]The Fourth Affiliated Hospital,Harbin Medical University,Harbin 150001,Heilongjiang,China[25]Cancer center,The First People's Hospital of Foshan,Foshan 528000,Guangdong,China[26]Department of Gastrointestinal Tumor Surgery,The First Affiliated Hospital,Xiamen University,Xiamen 361003,Fujian,China[27]Department of Nutrition,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China[28]Department of Nutrition,Tianjin Third Central Hospital,Tianjin 300170,China[29]Department of Surgery,The First Affiliated Hospital of Jinan University,Guangzhou 510632,Guangdong,China[30]Department of General Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,Jiangsu,China[31]Department of Gastrointestinal Surgery,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China[32]Department of Radiation and Medical Oncology,People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China[33]Department of Clinical Nutrition,Peking University Cancer Hospital and Institute,Beijing 100142,China[34]Department of Nutrition,Third Affiliated Hospital of Kunming Medical University,Tumor Hospital of Yunnan Province,Kunming 650118,Yunnan,China[35]Department of Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China华中科技大学同济医学院附属同济医院[36]Department of Nutrition,Guangzhou Red Cross Hospital,Guangzhou 510220,Guangdong,China[37]Department of Radiotherapy,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China四川省肿瘤医院[38]Department of Clinical Nutrition,Clifford Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510632,Guangdong,China[39]Department of Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shanxi,China[40]Department of Hepatobiliary Surgery,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China[41]Department of Clinical Nutrition,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China昆明医科大学附属第一医院[42]Department of Integrated Traditional Chinese and Western Medicine,Zhejiang Cancer Hospital&Key Laboratory of Traditional Chinese Medicine Oncology,Zhejiang Cancer Hospital,Hangzhou 310022,Zhejiang,China浙江省肿瘤医院[43]Department of Clinical Nutrition,the First Affiliated Hospital of Henan University,Kaifeng 475000,Henan,China[44]Department of Clinical Nutrition,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China[45]Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China华中科技大学同济医学院附属同济医院[46]Department of Colorectal Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China[47]Department of Gastrointestinal Surgery/Clinical Nutrition,Beijing Shijitan Hospital,Capital Medical University[48]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition[49]Key Laboratory of Cancer FSMP for State Market Regulation,Beijing 100038,China
Background Malnutrition is common in patients with cancer, and this adversely affects the survival and quality of life of patients. Chinese Society for Nutritional Oncology issued a multi-center, large-scale, long-term follow-up prospective study, the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China (INSCOC study) since 2013. This is an extension to the previous 2013-2020 study protocol. This study still sought to:① address the prognostic impact of nutritional factors and quality of life on cancer patient survival;② describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life. Methods and study design This is an observational, multi-centered, hospital-based prospective cohort study. Data collection will be performed at baseline (within 48 hours after patient admission), during the hospital stay and 30 days after hospital admission. Follow-up will be conducted for 1-20 years after enrollment. The primary outcome will be the all-cause mortality/overall survival, and secondary outcomes will be the length of hospital stay and costs of hospitalization. Study factors will include demographic characteristics, tumor characteristics, information about chronic diseases, hematological measurements (e.g., red blood cell count, total lymphocyte counts, hemoglobin, albumin, prealbumin, creatinine, C-reactive protein, IL-6), anthropometric measurements (e.g., height, weight, arm circumference, arm muscle circumference, triceps skinfold thickness, and waist circumference), body composition parameters, PG-SGA scores, quality of life (as indicated by the QLQ-C30 questionnaire), muscle mass (as indicated by the calf circumference), muscle strength (as indicated by the handgrip strength), muscle function (as indicated by the six-meter walking speed test) and physical status assessments (as indicated by the Karnofsky Performance Status scores). This clinical study protocol was approved by local Ethics Committees of all the participating hospitals. Written informed consent is required for each subject included. Discussion This multi-center, large-scale, long-term follow-up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes. The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations, and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future.
语种：
中文
第一作者：
第一作者机构：[1]Department of Nutrition,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China
共同第一作者：
通讯作者：
通讯机构：[3]Cancer Center of the First Hospital of Jilin University,Changchun 130021,Jilin China[47]Department of Gastrointestinal Surgery/Clinical Nutrition,Beijing Shijitan Hospital,Capital Medical University[48]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition[49]Key Laboratory of Cancer FSMP for State Market Regulation,Beijing 100038,China[*1]Cancer Center of the First Hospital of Jilin University, Changchun, Jilin 130021 China[*2]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University/ The 9th Clinical Medical College, Peking University, No. 10 Tieyi Road, Haidian District, Beijing 100038, China.
推荐引用方式(GB/T 7714)：
Hong Xia Xu,Chun Hua Song,Liang Yu Yin,等.Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China (INSCOC) Study: 2021 update[J].肿瘤营养学杂志（英文）.2022,7(2):11-21.
