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Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid.

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机构： [1]Department of Bioengineering, Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA [2]Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China [3]Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 510150, China [4]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China [5]School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, China [6]Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095, USA [7]Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA [8]California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA [9]Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA

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关键词： gelatin methacryloyl microneedle patches minimally invasive diagnostics skin interstitial fluid transdermal extraction

摘要：

The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2020]版：

大类 | 2 区

材料科学

小类 | 2 区化学综合 2 区物理化学 2 区纳米科技 2 区材料科学：综合 2 区物理：应用 2 区物理：凝聚态物理

最新[2023]版：

大类 | 2 区

材料科学

小类 | 1 区物理：应用 2 区化学：综合 2 区物理化学 2 区材料科学：综合 2 区纳米科技 2 区物理：凝聚态物理

第一作者：

第一作者机构： [1]Department of Bioengineering, Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA [2]Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China [3]Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 510150, China

通讯作者：

通讯机构： [1]Department of Bioengineering, Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA [6]Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095, USA [7]Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA [8]California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA [9]Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA

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Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid.

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