The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enhance the mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive transdermal administration. We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy.
基金：
China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M570745, 2016T90815]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030310229]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81602634]; National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [ZIA EB000073]
语种：
外文
被引次数：
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中科院(CAS)分区：
出版当年[2017]版：
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最新[2023]版：
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第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;[2]NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;[2]NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA;
推荐引用方式(GB/T 7714)：
Chen Wei,Tian Rui,Xu Can,et al.Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy[J].NATURE COMMUNICATIONS.2017,8(1):-.doi:10.1038/s41467-017-01764-1.
APA：
Chen, Wei,Tian, Rui,Xu, Can,Yung, Bryant C.,Wang, Guohao...&Chen, Xiaoyuan.(2017).Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy.NATURE COMMUNICATIONS,8,(1)
MLA：
Chen, Wei,et al."Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy".NATURE COMMUNICATIONS 8..1(2017):-
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