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Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.

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机构： [1]Department of Bioengineering University of California, Los Angeles Los Angeles, CA 90095, USA [2]Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California, Los Angeles Los Angeles CA 90095, USA [3]Department of Chemical and Biomolecular Engineering University of California, Los Angeles Los Angeles CA 90095, USA [4]School of Pharmacy Xi’an Jiaotong University Xi’an 710061 China [5]School of Nursing Nanjing University of Chinese Medicine Nanjing 210023 China [6]State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu 610041 China [7]Department of Biomedical Engineering School of Basic Medical Sciences Guangzhou Medical University Guangzhou 511436 China [8]Department of Chemistry Yazd University Yazd 89195 Iran [9]School of Dentistry The University of Queensland Herston QLD 4006, Australia [10]Department of Radiology David Geffen School of Medicine University of California, Los Angeles Los Angeles CA 90095, USA [11]Terasaki Institute for Biomedical Innovation Los Angeles CA 90064, USA [12]Jonsson Comprehensive Cancer Center University of California, Los Angeles Los Angeles CA 90095, USA

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关键词： 𝛽-cyclodextrin gelatin methacryloyl microneedles transdermal delivery water insoluble drugs

摘要：

Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2020]版：

大类 | 1 区

工程技术

小类 | 2 区工程：生物医学 2 区纳米科技 2 区材料科学：生物材料

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料 2 区纳米科技

第一作者：

第一作者机构： [1]Department of Bioengineering University of California, Los Angeles Los Angeles, CA 90095, USA [2]Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California, Los Angeles Los Angeles CA 90095, USA [3]Department of Chemical and Biomolecular Engineering University of California, Los Angeles Los Angeles CA 90095, USA

通讯作者：

通讯机构： [1]Department of Bioengineering University of California, Los Angeles Los Angeles, CA 90095, USA [2]Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California, Los Angeles Los Angeles CA 90095, USA [3]Department of Chemical and Biomolecular Engineering University of California, Los Angeles Los Angeles CA 90095, USA [10]Department of Radiology David Geffen School of Medicine University of California, Los Angeles Los Angeles CA 90095, USA [11]Terasaki Institute for Biomedical Innovation Los Angeles CA 90064, USA [12]Jonsson Comprehensive Cancer Center University of California, Los Angeles Los Angeles CA 90095, USA

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Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.

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