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Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime

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收录情况： ◇ SCIE

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机构： [1]College of Life Science, Jilin University, Changchun, PR China [2]Key Laboratory for Supramolecular Structure & Materials of Ministry of Education, Jilin University, Changchun, PR China [3]Sichuan Tumor Hospital & Institute, Chengdu, PR China

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关键词： PLGA microspheres solvent emulsification-diffusion DNA vaccine PEI/DNA complexes controlled release immunogenicity

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A novel approach involving the preparation of biodegradable PLGA microspheres containing entrapping complexes of DNA and polyethylenimine was developed to improve the delivery of DNA into antigen-presenting cells after intramuscular injection. Compared to the traditional biodegradable microspheres which release naked DNA, these microspheres released intact and penetrative PEI/DNA complexes over a period of 2 weeks in vitro. In addition, the DNA was not degraded during encapsulation in the PLGA microspheres, owing to the protection of polyethylenimine. After i.m. immunization, the microspheres induced significantly enhanced serum antibody responses 2-3 orders of magnitude greater than naked DNA. Additionally, in contrast to naked DNA, the microspheres induced potent CTL responses at a low dose. (C) 2007 Elsevier B.V. All rights reserved.

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出版当年[2008]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区药学

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出版当年[2008]版：

Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.4 最新[2023版] 4.8 最新五年平均 3.344 出版当年[2008版] 3.928 出版当年五年平均 2.611 出版前一年[2007版] 3.151 出版后一年[2009版]

第一作者：

第一作者机构： [1]College of Life Science, Jilin University, Changchun, PR China [2]Key Laboratory for Supramolecular Structure & Materials of Ministry of Education, Jilin University, Changchun, PR China

通讯作者：

通讯机构： [1]College of Life Science, Jilin University, Changchun, PR China [2]Key Laboratory for Supramolecular Structure & Materials of Ministry of Education, Jilin University, Changchun, PR China [*1]College of Life Science, Jilin University, Changchun 130012, PR China

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