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Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime

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收录情况： ◇ SCIE

作者：
Zhou, Xianfeng[1,2] * ; Liu, Bin[2] ; Yu, Xianghui[1,2] ; Zha, Xiao[2,3] ; Zhang, Xizhen[1] ; Wang, Xueyun[1] ; Jin, Yinghua[1] ; Wu, Yongge[1] ; Chen, Yue[1] ; Shan, Yaming[1] ; Chen, Yan[1] ; Liu, Junqiu[2] ; Kong, Wei[1,2,*1] ; Shen, Jiacong[2] ;
机构： [1]College of Life Science, Jilin University, Changchun, PR China [2]Key Laboratory for Supramolecular Structure & Materials of Ministry of Education, Jilin University, Changchun, PR China [3]Sichuan Tumor Hospital & Institute, Chengdu, PR China
出处：
DOI： 10.1016/j.ejpb.2007.09.006
ISSN：

关键词： PLGA microspheres solvent emulsification-diffusion DNA vaccine PEI/DNA complexes controlled release immunogenicity

摘要：
A novel approach involving the preparation of biodegradable PLGA microspheres containing entrapping complexes of DNA and polyethylenimine was developed to improve the delivery of DNA into antigen-presenting cells after intramuscular injection. Compared to the traditional biodegradable microspheres which release naked DNA, these microspheres released intact and penetrative PEI/DNA complexes over a period of 2 weeks in vitro. In addition, the DNA was not degraded during encapsulation in the PLGA microspheres, owing to the protection of polyethylenimine. After i.m. immunization, the microspheres induced significantly enhanced serum antibody responses 2-3 orders of magnitude greater than naked DNA. Additionally, in contrast to naked DNA, the microspheres induced potent CTL responses at a low dose. (C) 2007 Elsevier B.V. All rights reserved.

基金：
NSFC (20674029 and 30371317) to Wei Kong.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2008]版：
大类 | 3 区 医学
小类 | 3 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 药学
JCR分区：
出版当年[2008]版：
Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

第一作者：
第一作者机构： [1]College of Life Science, Jilin University, Changchun, PR China [2]Key Laboratory for Supramolecular Structure & Materials of Ministry of Education, Jilin University, Changchun, PR China
通讯作者：
通讯机构： [1]College of Life Science, Jilin University, Changchun, PR China [2]Key Laboratory for Supramolecular Structure & Materials of Ministry of Education, Jilin University, Changchun, PR China [*1]College of Life Science, Jilin University, Changchun 130012, PR China
推荐引用方式(GB/T 7714)：
Zhou Xianfeng,Liu Bin,Yu Xianghui,et al.Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime[J].EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS.2008,68(3):589-595.doi:10.1016/j.ejpb.2007.09.006.
APA：
Zhou, Xianfeng,Liu, Bin,Yu, Xianghui,Zha, Xiao,Zhang, Xizhen...&Shen, Jiacong.(2008).Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,68,(3)
MLA：
Zhou, Xianfeng,et al."Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 68..3(2008):589-595

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