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Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine

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WOS体系：

收录情况： ◇ SCIE

作者：
Zhou, Xianfeng[1,2] ; Liu, Bin[2] ; Yu, Xianghui[1,2] ; Zha, Xiao[2,3] ; Zhang, Xizhen[1] ; Chen, Yu[1] ; Wang, Xueyun[1] ; Jin, Yinghua[1] ; Wu, Yongge[1] ; Chen, Yue[1] ; Shan, Yaming[1] ; Chen, Yan[1] ; Liu, Junqiu[2] ; Kong, Wei[1,2,*1] ; Shen, Jiacong[2] ;
机构： [1]College of Life Science, Jilin University, Changchun 130012, PR China [2]Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, PR China [3]Sichuan Tumor Hospital & Institute, Chengdu 610041, PR China
出处：
DOI： 10.1016/j.jconrel.2007.05.018
ISSN：

关键词： mannose-bearing chitosan microspheres DNA vaccine target PEI/DNA complexes immunogenicity

摘要：
A novel approach involving the preparation of mannose-bearing chitosan microspheres with entrapping complexes of HBV DNA and PEI was developed to improve the delivery of DNA into antigen-presenting cells (APCs) after intramuscular (i.m.) injection. Compared with the traditional chitosan microspheres, the microspheres could quickly release intact and penetrative PEI/DNA complexes. What's more, chitosan was modified with mannose to target the primary APCs such as dendritic cells (DCs) owing to the high density of mannose receptors expressing on the surface of immature DCs. After i.m. immunization, the microspheres induced significantly enhanced serum antibody and cytotoxic T lymphocyte (CTL) responses in comparison to naked DNA. (C) 2007 Elsevier B.V. All rights reserved.

基金：
NSFC (20674029 and 30371317) to Wei Kong.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2007]版：
大类 | 2 区 医学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 化学：综合 1 区 药学
JCR分区：
出版当年[2007]版：
Q1 PHARMACOLOGY & PHARMACY Q1 CHEMISTRY, MULTIDISCIPLINARY
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2007版] 出版当年五年平均 出版前一年[2006版] 出版后一年[2008版]

第一作者：
第一作者机构： [1]College of Life Science, Jilin University, Changchun 130012, PR China [2]Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, PR China
通讯作者：
通讯机构： [1]College of Life Science, Jilin University, Changchun 130012, PR China [2]Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, PR China [*1]College of Life Science, Jilin University, Changchun 130012, PR China
推荐引用方式(GB/T 7714)：
Zhou Xianfeng,Liu Bin,Yu Xianghui,et al.Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine[J].JOURNAL OF CONTROLLED RELEASE.2007,121(3):200-207.doi:10.1016/j.jconrel.2007.05.018.
APA：
Zhou, Xianfeng,Liu, Bin,Yu, Xianghui,Zha, Xiao,Zhang, Xizhen...&Shen, Jiacong.(2007).Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine.JOURNAL OF CONTROLLED RELEASE,121,(3)
MLA：
Zhou, Xianfeng,et al."Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine".JOURNAL OF CONTROLLED RELEASE 121..3(2007):200-207

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