详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Jiangxi Provincial Key Laboratory of Additive Manufacturing of Implantable Medical Device, Jiangxi University of Science and Technology, Nanchang 330013, China [2]Chongqing Academy of Metrology and Quality Inspection, Chongqing 401121, China [3]School of Science, Nanchang Institute of Technology, Nanchang 330099, China [4]The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China [5]NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China [6]Sichuan Provincial Engineering Research Center of Functional Development and Application of High Performance Special Textile Materials, Chengdu Textile College, Chengdu 611731, China [7]State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

出处：

DOI：

ISSN：

关键词： Nitric oxide Controlled release Upconversion nanoparticles

摘要：

The photosensitive S-nitrosocysteine (CysNO) could respond to light irradiation to produce nitric oxide (NO), exhibiting tremendous potential in accelerating peripheral nerve regeneration. However, its further application was limited by the burst release of NO and the requirement for ultraviolet excitation with low tissue penetration. Herein, a near-infrared-triggered NO controlled release nanosystem UCNP@ZIF-8/CysNO consisting of an upconversion nanoparticle (UCNP) core and zeolitic imidazolate framework-8 (ZIF-8) shell loading with CysNO was constructed, and then blended with poly-l-lactic acid powder to fabricate nerve scaffold by laser additive manufacturing technique. Once irradiated by near-infrared light, UCNP emitted ultraviolet light, triggering the S-NO cleavage of CysNO to generate NO, thereby achieving deep penetration therapy. In addition, the spatial confinement effect of 2-methylimidazole skeleton structure in ZIF-8 could effectively ensure the controlled release of NO. The Griess method test demonstrated that the scaffold exhibited sustained and stable NO release kinetics, as well as excellent near-infrared controllability. Immunofluorescence staining showed that the released NO upregulated the expression of neuronal markers Nestin and GFAP, indicating that the stem cells differentiated into neurons. Further mechanism revealed that the upregulated marker expression might be attributed to the enhanced Ca2+ influx. Consequently, this work might provide a novel perspective for nerve repair.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2024]版：

无

最新[2023]版：

大类 | 1 区

化学

小类 | 2 区物理化学

第一作者：

第一作者机构： [1]Jiangxi Provincial Key Laboratory of Additive Manufacturing of Implantable Medical Device, Jiangxi University of Science and Technology, Nanchang 330013, China

通讯作者：

通讯机构： [1]Jiangxi Provincial Key Laboratory of Additive Manufacturing of Implantable Medical Device, Jiangxi University of Science and Technology, Nanchang 330013, China [4]The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China [5]NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China [7]State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration

文献详情

相关文献