机构：[1]Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China四川省人民医院[2]School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China四川省人民医院[3]Department of Pharmacy, The People’s Hospital of Leshan, Leshan, Sichuan 614000, China[4]Institute of Organ Transplantation, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China四川省人民医院
Tumor cell metabolism is characterized by abundant glucose consumption and aerobic glycolysis. And pyruvate kinase M2 (PKM2) plays a decisive role in glycolysis, significantly contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis and apoptosis. To date, researchers have unraveled the potential of pyruvate kinase M2 as an antitumor target, which suggests a new orientation for oncotherapy. Herein, we focus on the role of pyruvate kinase M2 in tumor cell development and its function as a potential new therapeutic target for tumor treatment. Besides, research actuality on pyruvate kinase M2-dependent glycometabolism and signaling pathway in tumors is also summarized, providing valuable suggestions for further study in this field.
基金：
Sichuan Health and Family Planning Commission Funding [16ZD0253]; Sichuan National Science Research Funding [2015JY0183]; Sichuan Provincial People's Hospital; Sichuan Scientific Research Grant for Returned Overseas Chinese Scholars; Science and Technology Department of Sichuan Province, China [14010159]; Sichuan Provincial People's Hospital [2015QN08]
