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PKM2 in carcinogenesis and oncotherapy

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机构： [1]Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China [2]School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China [3]Department of Pharmacy, The People’s Hospital of Leshan, Leshan, Sichuan 614000, China [4]Institute of Organ Transplantation, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China

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关键词： Aerobic glycolysis Carcinogenesis Oncotherapy PKM2 Warburg effect

摘要：

Tumor cell metabolism is characterized by abundant glucose consumption and aerobic glycolysis. And pyruvate kinase M2 (PKM2) plays a decisive role in glycolysis, significantly contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis and apoptosis. To date, researchers have unraveled the potential of pyruvate kinase M2 as an antitumor target, which suggests a new orientation for oncotherapy. Herein, we focus on the role of pyruvate kinase M2 in tumor cell development and its function as a potential new therapeutic target for tumor treatment. Besides, research actuality on pyruvate kinase M2-dependent glycometabolism and signaling pathway in tumors is also summarized, providing valuable suggestions for further study in this field. © 2017 He et al.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 2 区肿瘤学 3 区细胞生物学

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第一作者机构： [1]Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China

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通讯机构： [1]Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China

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