机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China[2]Sichuan Lung Cancer Institute, Sichuan Lung Cancer Center,West China Hospital, Sichuan University, Chengdu, China四川大学华西医院
Most tumor cells show different metabolic pathways than normal cells. Even under the conditions of sufficient oxygen, they produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol, which is known as aerobic glycolysis or the Warburg effect. Lung cancer is a malignant tumor with one of the highest incidence and mortality rates in the world at present. However, the exact mechanisms underlying lung cancer development remain unclear. The three key enzymes of glycolysis are hexokinase, phosphofructokinase, and pyruvate kinase. Lactate dehydrogenase catalyzes the transfer of pyruvate to lactate. All four enzymes have been reported to be overexpressed in tumors, including lung cancer, and can be regulated by many oncoproteins to promote tumor proliferation, migration, and metastasis with dependence or independence of glycolysis. The discovery of aerobic glycolysis in the 1920s has provided new means and potential therapeutic targets for lung cancer.
基金：
This study was supported by grants from the State Key
Development Program of Basic Research of China (No.
2010CB529405, to Qinghua Zhou), the National High Technology
Research and Development Program of China (No.
2012AA02A502, to Qinghua zhou), the National Natural
Science Foundation of China (No.81302002, to Xuebing Li),
the Key Project of Science and Technology of Sichuan Province (No. 06SG005-002-2, to Qinghua Zhou) and the
Tianjin Natural Science Foundation (No. 14JCQNJC12300,
to Xuebing Li).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学4 区呼吸系统
最新[2023]版：
大类|3 区医学
小类|4 区肿瘤学4 区呼吸系统
第一作者：
第一作者机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China
通讯作者：
通讯机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China[2]Sichuan Lung Cancer Institute, Sichuan Lung Cancer Center,West China Hospital, Sichuan University, Chengdu, China[*1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, no. 154 Anshan Street, Heping District, Tianjin 300052, China.
推荐引用方式(GB/T 7714)：
Xue-bing Li,Jun-dong Gu,Qing-hua Zhou.Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy.[J].Thoracic cancer.2015,6(1):17-24.doi:10.1111/1759-7714.12148.
APA：
Xue-bing Li,Jun-dong Gu&Qing-hua Zhou.(2015).Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy..Thoracic cancer,6,(1)
MLA：
Xue-bing Li,et al."Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy.".Thoracic cancer 6..1(2015):17-24
