机构：[1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China[2]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China[3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, People’s Republic of China
Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no exception. Breast cancer continues to be the second leading cause of cancer-associated mortality in women worldwide. However, the precise role of aerobic glycolysis in the development of BC remains elusive. Therefore, the present review attempts to address the implication of key enzymes of the aerobic glycolytic pathway including hexokinase (HK), phosphofructokinase (PFK) and pyruvate kinase (PK), glucose transporters (GLUTs), together with related signaling pathways including protein kinase B(PI3K/AKT), mammalian target of rapamycin (mTOR) and adenosine monophosphate-activated protein kinase (AMPK) and transcription factors (c-myc, p53 and HIF-1) in the research of BC. Thus, the review of aerobic glycolysis in BC may evoke novel ideas for the BC treatment.
基金：
This work was supported by grants from the Union Project of
Luzhou City and the Southwest Medical University (Nos. 14JC0144,
2013LZLY-J40).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China
通讯作者：
推荐引用方式(GB/T 7714)：
Z. Wu,J. Wu,Q. Zhao,et al.Emerging roles of aerobic glycolysis in breast cancer.[J].Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.2020,22(5):631-646.doi:10.1007/s12094-019-02187-8.
APA：
Z. Wu,J. Wu,Q. Zhao,S. Fu&J. Jin.(2020).Emerging roles of aerobic glycolysis in breast cancer..Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico,22,(5)
MLA：
Z. Wu,et al."Emerging roles of aerobic glycolysis in breast cancer.".Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 22..5(2020):631-646
