详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Pathology, Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, No. 55 Dongshun Road, Gaoping District, Nanchong, Sichuan, 637100, China. [2]Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China. [3]Ultrasonography Lab, Nanchong Oriental Hospital, Nanchong, Sichuan, 637000, China.

出处：

DOI：

ISSN：

摘要：

Pancreatic cancer (PC) is an aggressive malignant disease. Pancreatic ductal adenocarcinoma (PDAC) is a main type of PDAC. The inhibition of aerobic glycolysis in PC cells is one of the approaches to treat PDAC. WD repeat protein 79 (WDR79) acts as a scaffold protein and is involved in several physiological processes. Since WDR79 affects the progression of several types of cancers, whereas its role in PDAC remains unclear. This study was aimed to investigate the role of WDR79 in the progression of PDAC and clarify the mechanism. We found that WDR79 was highly expressed in PDAC cells. Knockdown of WDR79 inhibited the growth as well as the motility of PDAC cells, while overexpression of WDR79 contributed to the growth and motility. The ablation of WDR79 restrained aerobic glycolysis of PDAC cells. Mechanically, we found that WDR79 depletion increased SIRT4 expression by suppressing UHRF1 expression, which counteracted the function of WDR79 in PDAC. We thought that WDR79 could serve as a target for treating PDAC.© 2023 the author(s), published by De Gruyter.

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

第一作者：

第一作者机构： [1]Department of Pathology, Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, No. 55 Dongshun Road, Gaoping District, Nanchong, Sichuan, 637100, China. [2]Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.

通讯作者：

通讯机构： [1]Department of Pathology, Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, No. 55 Dongshun Road, Gaoping District, Nanchong, Sichuan, 637100, China. [2]Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：