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Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application

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机构： [1]Department of Clinical Laboratory, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, China [2]Assisted Reproductive Center, Women’s & Children’s Hospital of Northwest, Xi’an, Shaanxi, China [3]University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Vodnany, Czech Republic [4]Department of Evolution, Ecology and Behaviour, University of Liverpool, Liverpool, UK [5]Medical Center of Hematology, the Second Affiliated Hospital, Army Medical University, Chongqing, Sichuan, China [6]Changsha Medical University, Changsha, Hunan, China

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关键词： Mesenchymal stem cells Heterogeneity Cancer therapy

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Human mesenchymal stem cells (hMSCs) are mesoderm-derived adult stem cells with self-proliferation capacity, pluripotent differentiation potency, and excellent histocompatibility. These advantages make hMSCs a promising tool in clinical application. However, the majority of clinical trials using hMSC therapy for diverse human diseases do not achieve expectations, despite the prospective pre-clinical outcomes in animal models. This is partly attributable to the intrinsic heterogeneity of hMSCs. In this review, the cause of heterogeneity in hMSCs is systematically discussed at multiple levels, including isolation methods, cultural conditions, donor-to-donor variation, tissue sources, intra-tissue subpopulations, etc. Additionally, the effect of hMSCs heterogeneity on the contrary role in tumor progression and immunomodulation is also discussed. The attempts to understand the cellular heterogeneity of hMSCs and its consequences are important in supporting and improving therapeutic strategies for hMSCs.Copyright © 2024 Elsevier GmbH. All rights reserved.

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大类 | 4 区医学

小类 | 4 区病理学

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第一作者机构： [1]Department of Clinical Laboratory, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, China

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