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Current therapeutic strategies for respiratory diseases using mesenchymal stem cells.

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机构: [1]Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy and Cancer Center,West China HospitalSichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China
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关键词: acute respiratory distress syndrome asthma chronic obstructive pulmonary disease idiopathic pulmonary fibrosis mesenchymal stem cells

摘要:
Mesenchymal stromal/stem cells (MSCs) have a great potential to proliferate, undergo multi-directional differentiation, and exert immunoregulatory effects. There is already much enthusiasm for their therapeutic potentials for respiratory inflammatory diseases. Although the mechanism of MSCs-based therapy has been well explored, only a few articles have summarized the key advances in this field. We hereby provide a review over the latest progresses made on the MSCs-based therapies for four types of inflammatory respiratory diseases, including idiopathic pulmonary fibrosis, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and asthma, and the uncovery of their underlying mechanisms from the perspective of biological characteristics and functions. Furthermore, we have also discussed the advantages and disadvantages of the MSCs-based therapies and prospects for their optimization.© 2021 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 医学:研究与实验
第一作者:
第一作者机构: [1]Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy and Cancer Center,West China HospitalSichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China
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通讯作者:
通讯机构: [1]Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy and Cancer Center,West China HospitalSichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China [*1]Laboratory of Stem Cell and TissueEngineering, Orthopedic Research Institute, Med-XCenter for Materials, StateKey Laboratory ofBiotherapy, West ChinaHospital, Sichuan University, Chengdu,China, 610041, China.
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