详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Role of T-box genes in cancer, epithelial-mesenchymal transition, and cancer stem cells.

文献详情

资源类型：

Pubmed体系：

收录情况： ◇ 预警期刊

作者：

机构： [1]Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA. [2]Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Department of Outpatient, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. [4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

出处：

DOI：

ISSN：

关键词： cancer stem cells cancer therapy epithelial‐mesenchymal transition T‐box transcription factor TBX genes

摘要：

Sharing a common DNA binding motif called T-box, transcription factor T-box gene family controls embryonic development and is also involved in cancer progression and metastasis. Cancer metastasis shows therapy resistance and involves complex processes. Among them, epithelial-mesenchymal transition (EMT) triggers cancer cell invasiveness and the acquisition of stemness of cancer cells, called cancer stem cells (CSCs). CSCs are a small fraction of tumor bulk and are capable of self-renewal and tumorsphere formation. Recent progress has highlighted the critical roles of T-box genes in cancer progression, EMT, and CSC function, and such regulatory functions of T-box genes have emerged as potential therapeutic candidates for cancer. Herein we summarize the current understanding of the regulatory mechanisms of T-box genes in cancer, EMT, and CSCs, and discuss the implications of targeting T-box genes as anticancer therapeutics.© 2021 Wiley Periodicals LLC.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

第一作者：

第一作者机构： [1]Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

通讯作者：

通讯机构： [2]Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Department of Outpatient, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. [4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. [*1]Department of Oral and Maxillofacial—Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University, 639, Zhi Zao Ju Road, Shanghai 200011, China [*2]Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, 2nd section, West Yi Huan Road, Chengdu 610072, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Role of T-box genes in cancer, epithelial-mesenchymal transition, and cancer stem cells.

文献详情

相关文献