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Glioma-associated mesenchymal stem cells

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机构： [1]Department of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Chongqing, 400038, China. [2]Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China. [3]International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Chongqing, 400038, China. [4]Key Laboratory of Cancer Immunopathology, Ministry of Education, Chongqing, 400038, China. [5]Jin-feng Laboratory, Chongqing, 401329, China.

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Recent studies revealed that glioma-associated mesenchymal stem cells play instrumental roles in tumorigenesis and tumor progression and cannot be ignored as a cellular component of the glioma microenvironment. Nevertheless, the origin of these cells and their roles are poorly understood. The only relevant studies have shown that glioma-associated mesenchymal stem cells play a large role in promoting tumor proliferation, invasion and angiogenesis. The following review provides a comprehensive summary of their discovery and definition, origin, differences from other tissue-derived mesenchymal stem cells, spatial distribution, functions, and prognostic and therapeutic opportunities to deepen the understanding of these cells and provide new insight into the treatment of glioma.© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学 1 区神经科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学 1 区神经科学

第一作者：

第一作者机构： [1]Department of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Chongqing, 400038, China. [2]Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China. [3]International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Chongqing, 400038, China. [4]Key Laboratory of Cancer Immunopathology, Ministry of Education, Chongqing, 400038, China. [5]Jin-feng Laboratory, Chongqing, 401329, China.

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通讯作者：

通讯机构： [1]Department of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Chongqing, 400038, China. [3]International Joint Research Center for Precision Biotherapy, Ministry of Science and Technology, Chongqing, 400038, China. [4]Key Laboratory of Cancer Immunopathology, Ministry of Education, Chongqing, 400038, China. [5]Jin-feng Laboratory, Chongqing, 401329, China. [*1]No. 30, Gaotanyan Street, Shapingba District, Chongqing, China

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