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Role of T-box genes in cancer, epithelial-mesenchymal transition, and cancer stem cells.

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收录情况： ◇ SCIE

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机构： [1]Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA [2]Department of Oral and Maxillofacial—Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [3]Department of Outpatient, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China [4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China

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关键词： cancer stem cells cancer therapy epithelial‐mesenchymal transition T‐box transcription factor TBX genes

摘要：

Sharing a common DNA binding motif called T-box, transcription factor T-box gene family controls embryonic development and is also involved in cancer progression and metastasis. Cancer metastasis shows therapy resistance and involves complex processes. Among them, epithelial-mesenchymal transition (EMT) triggers cancer cell invasiveness and the acquisition of stemness of cancer cells, called cancer stem cells (CSCs). CSCs are a small fraction of tumor bulk and are capable of self-renewal and tumorsphere formation. Recent progress has highlighted the critical roles of T-box genes in cancer progression, EMT, and CSC function, and such regulatory functions of T-box genes have emerged as potential therapeutic candidates for cancer. Herein we summarize the current understanding of the regulatory mechanisms of T-box genes in cancer, EMT, and CSCs, and discuss the implications of targeting T-box genes as anticancer therapeutics.© 2021 Wiley Periodicals LLC.

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出版当年[2022]版：

大类 | 2 区生物学

小类 | 3 区生化与分子生物学 3 区细胞生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2022]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3 最新[2023版] 3.1 最新五年平均 4 出版当年[2022版] 3.7 出版当年五年平均 4.481 出版前一年[2021版] 3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA

通讯作者：

通讯机构： [2]Department of Oral and Maxillofacial—Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [3]Department of Outpatient, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China [4]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China [*1]Department of Oral and Maxillofacial—Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University, 639, Zhi Zao Ju Road, Shanghai 200011, China. [*2]Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, 2nd section, West Yi Huan Road, Chengdu 610072, China.

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Role of T-box genes in cancer, epithelial-mesenchymal transition, and cancer stem cells.

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