高级检索
当前位置: 首页 > 详情页

Tough Gelatin Hydrogel for Tissue Engineering

文献详情

资源类型:
Pubmed体系:
机构: [1]State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, P. R. China. [2]National Innovation Center for Advanced Medical Devices, Shenzhen, 457001, P. R. China. [3]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chengdu, 610041, P. R. China. [4]Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, P. R. China. [5]State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. [6]Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, College of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. [7]Cancer Center, Zhejiang University, Hangzhou, 310058, P. R. China.
出处:

关键词: gelation hydrogel tendon regeneration tissue engineering tough hydrogel

摘要:
Tough hydrogel has attracted considerable interest in various fields, however, due to poor biocompatibility, nondegradation, and pronounced compositional differences from natural tissues, it is difficult to be used for tissue regeneration. Here, a gelatin-based tough hydrogel (GBTH) is proposed to fill this gap. Inspired by human exercise to improve muscle strength, the synergistic effect is utilized to generate highly functional crystalline domains for resisting crack propagation. The GBTH exhibits excellent tensile strength of 6.67 MPa (145-fold that after untreated gelation). Furthermore, it is directly sutured to a ruptured tendon of adult rabbits due to its pronounced toughness and biocompatibility, self-degradability in vivo, and similarity to natural tissue components. Ruptured tendons can compensate for mechanotransduction by GBTH and stimulate tendon differentiation to quickly return to the initial state, that is, within eight weeks. This strategy provides a new avenue for preparation of highly biocompatible tough hydrogel for tissue regeneration.© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

基金:
语种:
PubmedID:
中科院(CAS)分区:
出版当年[2023]版:
大类 | 1 区 材料科学
小类 | 1 区 化学:综合 1 区 材料科学:综合 2 区 纳米科技
最新[2023]版:
大类 | 1 区 材料科学
小类 | 1 区 化学:综合 1 区 材料科学:综合 2 区 纳米科技
第一作者:
第一作者机构: [1]State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, P. R. China. [2]National Innovation Center for Advanced Medical Devices, Shenzhen, 457001, P. R. China.
共同第一作者:
通讯作者:
通讯机构: [1]State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, P. R. China. [2]National Innovation Center for Advanced Medical Devices, Shenzhen, 457001, P. R. China. [5]State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. [6]Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, College of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, P. R. China. [7]Cancer Center, Zhejiang University, Hangzhou, 310058, P. R. China.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:43378 今日访问量:0 总访问量:3120 更新日期:2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持:重庆聚合科技有限公司 地址:成都市人民南路四段55号