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Stimuli-Responsive Delivery of Growth Factors for Tissue Engineering.

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机构: [1]Department of Bioengineering, California NanoSystems Institute and Center for Minimally Invasive, Therapeutics (C-MIT) University of California, Los Angeles, Los Angeles, CA 90095, USA [2]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China [3]School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, China [4]Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA [5]Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [6]State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China [7]School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China [8]Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China [9]Jonsson Comprehensive Cancer Center, Department of Radiology University of California-Los Angeles, Los Angeles, CA 90095, USA
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关键词: growth factors regenerative medicine stimuli-responsive delivery tissue engineering

摘要:
Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half-life within the physiological microenvironment and significant side effects caused by off-target effects or improper dosage. "Smart" materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on-demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these "smart" materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease-specific stimuli. The aim of this review is to summarize the current research on stimuli-responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such "smart" materials and perspectives on future applications of stimuli-responsive GF delivery for tissue regeneration are also discussed. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2020]版:
大类 | 1 区 工程技术
小类 | 2 区 工程:生物医学 2 区 纳米科技 2 区 材料科学:生物材料
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学 2 区 材料科学:生物材料 2 区 纳米科技
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第一作者机构: [1]Department of Bioengineering, California NanoSystems Institute and Center for Minimally Invasive, Therapeutics (C-MIT) University of California, Los Angeles, Los Angeles, CA 90095, USA [2]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
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通讯机构: [1]Department of Bioengineering, California NanoSystems Institute and Center for Minimally Invasive, Therapeutics (C-MIT) University of California, Los Angeles, Los Angeles, CA 90095, USA [4]Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA [9]Jonsson Comprehensive Cancer Center, Department of Radiology University of California-Los Angeles, Los Angeles, CA 90095, USA
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