机构：[1]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China[2]Department of Advanced Oral Sciences and Therapeutics, University of MarylandDental School, Baltimore, MD, USA[3]State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Deptartment of Cariology and Endodonics WestChina Hospital of Stomatology, Sichuan University, Chengdu, China[4]Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat-senUniversity, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China[5]Volpe Research Center, American Dental Association Foundation, National Institute ofStandards and Technology, Gaithersburg, MD, USA[6]Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD, USA[7]Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals. Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material's responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|1 区医学
小类|1 区细胞与组织工程
最新[2023]版：
大类|1 区医学
小类|1 区细胞与组织工程
第一作者：
第一作者机构：[1]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China[2]Department of Advanced Oral Sciences and Therapeutics, University of MarylandDental School, Baltimore, MD, USA
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China[2]Department of Advanced Oral Sciences and Therapeutics, University of MarylandDental School, Baltimore, MD, USA[6]Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD, USA[7]Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
推荐引用方式(GB/T 7714)：
Zhang Ke,Wang Suping,Zhou Chenchen,et al.Advanced smart biomaterials and constructs for hard tissue engineering and regeneration.[J].Bone Research.2018,6:31.doi:10.1038/s41413-018-0032-9.
APA：
Zhang Ke,Wang Suping,Zhou Chenchen,Cheng Lei,Gao Xianling...&Xu Hockin H K.(2018).Advanced smart biomaterials and constructs for hard tissue engineering and regeneration..Bone Research,6,
MLA：
Zhang Ke,et al."Advanced smart biomaterials and constructs for hard tissue engineering and regeneration.".Bone Research 6.(2018):31
医学