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Receptor-Mediated NETosis on Neutrophils.

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机构： [1]Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China, [2]Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China, [3]Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China, [4]Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany

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关键词： neutrophil extracellular traps chemokine receptor Fc receptors complement receptors pattern recognition receptors

摘要：

Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse intracellular signaling cascades and regulates neutrophil effector functions, including phagocytosis, reactive oxygen species release, degranulation, and NET formation. However, overproduction of NETs is closely related to the occurrence of inflammation, autoimmune disorders, non-canonical thrombosis and tumor metastasis. Therefore, it is necessary to understand neutrophil activation signals and the subsequent formation of NETs, as well as the related immune regulation. In this review, we provide an overview of the immunoreceptor-mediated regulation of NETosis. The pathways involved in the release of NETs during infection or stimulation by noninfectious substances are discussed in detail. The mechanisms by which neutrophils undergo NETosis help to refine our views on the roles of NETs in immune protection and autoimmune diseases, providing a theoretical basis for research on the immune regulation of NETs.Copyright © 2021 Chen, Li, Sun, Hu, Liu, Herrmann, Zhao and Muñoz.

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

第一作者：

第一作者机构： [1]Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China, [2]Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China, [3]Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China,

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通讯作者：

通讯机构： [1]Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China, [2]Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China, [3]Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China,

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Receptor-Mediated NETosis on Neutrophils.

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