Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predominant role of NETs in cancer is emerging. Increasing evidence has confirmed that many stimuli can facilitate NET formation in an NADPH oxidase (NOX)-dependent/NOX-independent manner. In cancer, NETs have been linked to cancer progression, metastasis, and cancer-associated thrombosis. In this review, we aimed to summarize the current available knowledge regarding NET formation and focused on the role of NETs in cancer biological behaviors. The potential target for cancer therapy will be further discussed.
第一作者机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Pathol, Beijing 100038, Peoples R China
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推荐引用方式(GB/T 7714)：
Chen Yue,Hu Haoyue,Tan Songtao,et al.The role of neutrophil extracellular traps in cancer progression, metastasis and therapy[J].EXPERIMENTAL HEMATOLOGY & ONCOLOGY.2022,11(1):doi:10.1186/s40164-022-00345-3.
APA：
Chen, Yue,Hu, Haoyue,Tan, Songtao,Dong, Qionglan,Fan, Xue...&He, Jun.(2022).The role of neutrophil extracellular traps in cancer progression, metastasis and therapy.EXPERIMENTAL HEMATOLOGY & ONCOLOGY,11,(1)
MLA：
Chen, Yue,et al."The role of neutrophil extracellular traps in cancer progression, metastasis and therapy".EXPERIMENTAL HEMATOLOGY & ONCOLOGY 11..1(2022)
