机构：[1]West China Medical Center, Sichuan University, Chengdu, Sichuan 610041四川大学华西医院[2]School of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China[3]Department of Oncology and Pathology, Karolinska Institute, Cancer Centre Karolinska,SE-171 76 Stockholm, Sweden[4]West China Second University Hospital, Sichuan University[5]Outpatient Building, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Epithelial-mesenchymal transition (EMT) is a biological process that is associated with cancer metastasis and invasion. In cancer, EMT promotes cell motility, invasion and distant metastasis. Interleukin (IL)-8 is highly expressed in tumors and may induce EMT. The IL-8/IL-8R axis has a vital role in EMT in carcinoma, which is regulated by several signaling pathways, including the transforming growth factor β-spleen associated tyrosine kinase/Src-AKT/extracellular signal-regulated kinase, p38/Jun N-terminal kinase-activating transcription factor-2, phosphoinositide 3-kinase/AKT, nuclear factor-κB and Wnt signaling pathways. Blocking the IL-8/IL-8R signaling pathway may be a novel strategy to reduce metastasis and improve patient survival rates. This review will cover IL-8-IL-8R signaling pathway in tumor epithelial-mesenchymal transition.
基金：
The present study was supported by the National Natural Science Foundation of China (grant no. 11262020) and the Foundation of Sichuan Provincial Science and Technology Program (grant nos. 2013JY0021, 2014SZ0002-15 and 2016SZ0020).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]West China Medical Center, Sichuan University, Chengdu, Sichuan 610041
共同第一作者：
通讯作者：
通讯机构：[1]West China Medical Center, Sichuan University, Chengdu, Sichuan 610041[2]School of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China[5]Outpatient Building, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China[*1]West China Medical Center, Sichuan University, 17 Section 3 Renmin South Road, Chengdu, Sichuan 610041, P.R. China[*2]Outpatient Building, West China Fourth Hospital, Sichuan University, 18 3rd Section, Renmin Nanlu Road, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
ZHIWEI ZHAO,SHICHAO WANG,YINGBO LIN,et al.Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis.[J].Oncology letters.2017,13(6):4577-4584.doi:10.3892/ol.2017.6034.
APA：
ZHIWEI ZHAO,SHICHAO WANG,YINGBO LIN,YALI MIAO,YE ZENG...&JIANG WU.(2017).Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis..Oncology letters,13,(6)
MLA：
ZHIWEI ZHAO,et al."Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis.".Oncology letters 13..6(2017):4577-4584
