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Comparative mRNA/micro-RNA co-expression network drives melanomagenesis by promoting epithelial-mesenchymal transition and vasculogenic mimicry signaling.

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机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China [2]Department of Oncology, Anyue Hospital of Traditional Chinese Medicine, Second Ziyang Hospital of Traditional Chinese Medicine, Ziyang, Sichuan, China [3]Department of Oncology, Chengdu Jinniu District People’s Hospital, Chengdu, Sichuan, China [4]Laboratory of Systems Biology and Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran [5]Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran [6]Department of Biology, Faculty of Science, University of Zanjan, Zanjan, Iran [7]Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan [8]Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China [9]Oncology Department, Luzhou People’s Hospital, Luzhou, Sichuan, China [10]Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran

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关键词： mRNA/micro-RNA co-expression Melanomagenesis Epithelial–mesenchymal transition Vasculogenic mimicry Biomarker

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This study aimed to identify a novel disease-associated differentially co-expressed mRNA-microRNA (miRNA) that is associated with vasculogenic mimicry (VM) and epithelial-to-mesenchymal transition (EMT) network at different stages of melanoma. By applying weighted gene co-expression network analysis, we constructed a VM+EMT biological network with the available microarray dataset downloaded from a public database. Quantitative real-time PCR, immunohistochemical staining, and CD31-periodic acid solution dual staining were performed to confirm the expression of genes associated with EMT and VM formation in subjects with malignant melanoma (n = 18) and primary melanoma (n = 13) and in healthy subjects (n = 10). Our findings suggested that phosphatidylserine-specific phospholipase A1-alpha (PLA1A) and dermokine (DMKN) genes function as oncogenes that trigger VM and EMT processes during melanomagenesis on interaction with miR-370, miR-563, and miR-770-5p. PLA1A and DMKN genes can be considered potential VM+EMT network-based diagnostic biomarkers for distinguishing between melanoma patients. We postulate that a network with altered PLA1A/miR-563 and DMNK/miR-770-5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. This study provides a potentially valuable approach for the early diagnosis and prognosis of melanoma progression.Copyright © 2021. Published by Elsevier Inc.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

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第一作者机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

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通讯机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China [*1]The Affiliated Hospital of Southwest Medical University, #25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province 646000,

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