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Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration

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机构： [1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA [2]Southwest Jiaotong University, Chengdu, Sichuan 610031, China [3]Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA [4]Department of Orthopaedics, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China [5]Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China [6]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA

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关键词： Epithelial-mesenchymal transition Mesenchymal tissue Regeneration SNAI TWIST ZEB

摘要：

The epithelial-mesenchymal transition transcription factors (EMT-TFs)-ZEB, SNAI, and TWIST families-have been extensively studied in embryonic development and tumor metastasis, providing valuable insight into their roles in cell behavior and transformation. These EMT-TFs have garnered increasing attention in the context of mesenchymal tissue regeneration, potentially contributing an approach for cell therapy. Given that dysregulated EMT-TF expression can impair cell survival and lineage differentiation, controlled regulation of their expression could offer significant advantages for tissue regeneration. However, there is a lack of comprehensive reviews to summarize the influence of the EMT-TFs on mesenchymal tissue regeneration and potential molecular mechanisms. This review explores the regulatory roles of ZEB, SNAI, and TWIST in the regeneration of bone, adipose, cartilage, muscle, and other mesenchymal tissues, with a focus on the underlying molecular signaling mechanisms. Gaining a deeper understanding of how EMT-TFs regulate cell proliferation, apoptosis, migration, and differentiation may offer new insights into the management of mesenchymal tissue repair and open novel avenues for enhancing tissue regeneration.Copyright © 2025 Elsevier Ltd. All rights reserved.

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大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区细胞生物学

第一作者：

第一作者机构： [1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA [2]Southwest Jiaotong University, Chengdu, Sichuan 610031, China

通讯作者：

通讯机构： [1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA [3]Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA [4]Department of Orthopaedics, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China [5]Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China [6]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA

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