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Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9.

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资源类型：
Pubmed体系：
作者：
Ma Dawei[1] ; Zhu Yan[2] ; Zhang Xiao[3] ; Zhang Jia[4] ; Chen Wei[5] ; Chen Xinyuan[5] ; Qian Yichun[5] ; Zhao Yanbin[5] ; Hu Tingting[5] ; Yao Zhangyu[5] ; Zhao Wei[6] ; Zhang Yuan[5] ; Liu Fangzhou[5] ;
机构： [1]Department of Pathology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China. [2]Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [3]The Key Laboratory of Antibody Technology, National Health Commission and Nanjing Medical University, Nanjing, China. [4]Department of Positron Emission Tomography/Computed Tomography (PET/CT) Center, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China. [5]Department of Head and Neck Surgery, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China. [6]School of Laboratory Medicine/Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-Origin Food, Chengdu Medical College, Chengdu, China.
出处：
DOI： 10.3389/fcell.2021.650004
ISSN：

关键词： thyroid cancer lncRNA RUNDC3A-AS1 miR-182-5p/ADAM9 in vivo mice model metastasis

摘要：
Long non-coding RNAs (lncRNAs) have been identified as influential indicators in variety of malignancies. Among which, LncRNA RUNDC3A-AS1 is reported to upregulate in thyroid cancer. However, the expression pattern and the pathological function of lncRNA RUNDC3A-AS1 in thyroid cancer is unclear. In this study, we examined the expression levels of lncRNA RUNDC3A-AS1 in the thyroid cancer tissues and cell lines via RT-qPCR analysis. The effects of RUNDC3A-AS1 on thyroid cancer cell metastasis were detected by transwell chamber assay, scratch assay in vitro and lung metastasis model in vivo. The results indicated that RUNDC3A-AS1 was highly expressed in the thyroid cancer tissues and cell lines. Functionally, knockdown of RUNDC3A-AS1 could repress the migration and invasion of thyroid cancer cells in vitro, and inhibit thyroid cancer metastasis to lung in vivo. Mechanistically, RUNDC3A-AS1 served as an inhibitor of miR-182-5p in tumor tissues and cell lines. RUNDC3A-AS1 inhibited the expression of miR-182-5p to increase the expression level of ADAM9, thus further aggravating the malignancy of thyroid cancer. Therefore, the RUNDC3A-AS1/miR-182-5p/ADAM9 axis may be a potential therapeutic target for the treatment of thyroid cancer metastasis. Copyright © 2021 Ma, Zhu, Zhang, Zhang, Chen, Chen, Qian, Zhao, Hu, Yao, Zhao, Zhang and Liu.

基金：
This work was supported by the National Natural Science Foundation of China (No. 81972555), the National Natural Youth Fund of China (No. 81902725) and the Research Foundation of Jiangsu Cancer Hospital (ZM201912 and ZM202004).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物学
小类 | 2 区 发育生物学 3 区 细胞生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 发育生物学 3 区 细胞生物学
第一作者：
第一作者机构： [1]Department of Pathology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Dawei,Zhu Yan,Zhang Xiao,et al.Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9.[J].Frontiers in cell and developmental biology.2021,9:650004.doi:10.3389/fcell.2021.650004.
APA：
Ma Dawei,Zhu Yan,Zhang Xiao,Zhang Jia,Chen Wei...&Liu Fangzhou.(2021).Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9..Frontiers in cell and developmental biology,9,
MLA：
Ma Dawei,et al."Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9.".Frontiers in cell and developmental biology 9.(2021):650004

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