Background: Tian Zhang is the correspondence author, not the first author. The correct first author is Yuan Tang. At the same time, please refer to the screenshot for the author order of the proof version we returned. Objectives: This study aimed to detect the health-related quality of life (HRQoL) of thyroid cancer (TC) patients and analyze the change tendency of TC patients' reported symptoms after surgery. Methods: A total of 102 TC patients who underwent thyroid surgery from September 2020 to January 2021 were included in this study and received a survey on HRQoL and disease-specific symptoms 1 month and 3 months after the surgery. Results: Almost all the patients experienced TC-specific symptoms after the surgery. The top 5 reported complaints 1 month after surgery were throat/mouth problems, voice problems, neuromuscular problems, concentration problems, and less interest in sex. However, 3 months postoperation, less interest in sex was the top reported complaint, followed by throat/mouth problems, voice problems, psychological problems, neuromuscular problems, and concentration problems. Meanwhile, the scores of most specific symptoms decreased with an increase in postoperative time, whereas the scores of less interest in sex increased. Fatigue, insomnia, and dyspnea were the most often reported common cancer-related symptoms for TC patients 1 and 3 months after the surgery. The scores of fatigue were much lower 3 months after post-operation than 1 month after the surgery. Conclusion: Throat/mouth problems, voice problems, neuromuscular problems, concentration problems, less interest in sex, and fatigue were the important patient-reported complaints that need more attention after the surgery.