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Characterizing dedifferentiation of thyroid cancer by integrated analysis.

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收录情况： ◇ EI ◇ 自然指数

作者：
Luo Han[1] * ; Xia Xuyang[2] * ; Kim Gyeong Dae[3] * ; Liu Yang[1] * ; Xue Zhinan[2] ; Zhang Lingyun[1] ; Shu Yang[2,4] ; Yang Tian[5] ; Chen Yan[2] ; Zhang Shouyue[2] ; Chen Haining[4] ; Zhang Weihan[4] ; Li Ruicen[6] ; Tang Huairong[6] ; Dong Birong[7] ; Fu Xianghui[2] ; Cheng Wei[2] ; Zhang Wei[8] ; Yang Li[2] ; Peng Yong[2] ; Dai Lunzhi[2] ; Hu Hongbo[2] ; Jiang Yong[5] ; Gong Changyang[2] ; Hu Yiguo[1,2] ; Zhu Jingqiang[1] ; Li Zhihui[1] ; Caulin Carlos[9] ; Wei Tao[1] ; Park Jihwan[3] ; Xu Heng[2,10] ;
机构： [1]Department of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and ParathyroidDisease, Frontiers Science Center for Disease-related Molecular Network,West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]State KeyLaboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Universityand Collaborative Innovation Center, Chengdu, Sichuan, China [3]School of Life Sciences,Gwangju Institute of Science and Technology (GIST), Gwangju, Republic ofKorea [4]Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy,West China Hospital, Sichuan University, Chengdu, Sichuan, China [5]Department ofPathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China [6]HealthPromotion Center, West China Hospital, Sichuan University, Chengdu, Sichuan,China [7]National Clinical Research Center for Geriatrics, Chengdu, Sichuan, China [8]Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics,Xiangya Hospital, Central South University, Changsha, Hunan, China [9]Departmentof Otolaryngology—Head & Neck Surgery and University of Arizona Cancer Center,University of Arizona, Tucson, AZ, USA [10]Department of Laboratory Medicine,Precision Medicine Center, State Key Laboratory of Biotherapy, West China Hospital,Sichuan University, Chengdu, Sichuan, China
出处：
DOI： 10.1126/sciadv.abf3657

摘要：
Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Moreover, a potential functional role of CREB3L1 on ATC development was revealed by integrated analyses of copy number alteration and transcriptional regulatory network. Multiple genes in differentiation-related pathways (e.g., EMT) were involved as the downstream targets of CREB3L1, increased expression of which can thus predict higher relapse risk of PTC. Collectively, our study provided insights into the heterogeneity and molecular evolution of thyroid cancer and highlighted the potential driver role of CREB3L1 in its dedifferentiation process.Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

基金：
National Key R&D Program of China (2017YFC0907504); the Sichuan Science and Technology Program (2019YFS0333); the National Natural Science Foundation of China (81973408, 82002569, and 81973408); the China Postdoctoral Science Foundation (2019 M653416); the Post-Doctor Research Project, West China Hospital, Sichuan University (2018HXBH004); the International Cooperation Project of Chengdu Municipal Science and Technology Bureau (2020-GH02-00017-HZ); and “1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University” (ZYJC18035, ZYJC18025, ZY2017309, ZYYC20003, ZY2017201, ZYJC18003, and ZYJC21006). J.P. was supported by the Samsung Science and Technology Foundation (SSTF-BA2001-11).
语种：
外文
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出版当年[2021]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
第一作者：
第一作者机构： [1]Department of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and ParathyroidDisease, Frontiers Science Center for Disease-related Molecular Network,West China Hospital, Sichuan University, Chengdu, Sichuan, China
共同第一作者：
通讯作者：
通讯机构： [2]State KeyLaboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Universityand Collaborative Innovation Center, Chengdu, Sichuan, China [10]Department of Laboratory Medicine,Precision Medicine Center, State Key Laboratory of Biotherapy, West China Hospital,Sichuan University, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Luo Han,Xia Xuyang,Kim Gyeong Dae,et al.Characterizing dedifferentiation of thyroid cancer by integrated analysis.[J].Science advances.2021,7(31):doi:10.1126/sciadv.abf3657.
APA：
Luo Han,Xia Xuyang,Kim Gyeong Dae,Liu Yang,Xue Zhinan...&Xu Heng.(2021).Characterizing dedifferentiation of thyroid cancer by integrated analysis..Science advances,7,(31)
MLA：
Luo Han,et al."Characterizing dedifferentiation of thyroid cancer by integrated analysis.".Science advances 7..31(2021)

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