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Magnetic targeting of super-paramagnetic iron oxide nanoparticle labeled myogenic-induced adipose-derived stem cells in a rat model of stress urinary incontinence.

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机构: [1]Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, 200233, Shanghai, China [2]Department of Urology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China,610041, Chengdu, China [3]Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine Winston-Salem, 27157, North Carolina, USA [4]Department of General Educational Development, Faculty of Science and Information Technology, Daffodil International University, 1207, Dhaka, Bangladesh [5]Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University, 200240, Shanghai, China [6]Department of Pharmacy, Taizhou Central Hospital, 318000, Zhejiang, China [7]Institute for Intestinal Diseases, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 200072, Shanghai, China
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关键词: Magnetic targeting Stress urinary incontinence Cell transplantation Adipose derived stem cells

摘要:
Cell-based injectable therapy utilizing stem cells is a promising approach for the treatment of stress urinary incontinence (SUI). Applying a magnetically controlled cell delivery approach has enormous potential to enhance cell retention capability within the specified site. To assess the therapeutic efficacy of cellular magnetic targeting, we applied an external magnetic force to target an adipose-derived stem cell based therapy in a rat model of SUI. The results revealed that magnetic attraction of transplanted cells under the magnetic field was generated by cell uptake of superparamagnetic iron oxide nanoparticles in vitro. More importantly, magnetic targeting improved the retention rate of transplanted cells and facilitated the restoration of sphincter structure and function in a rat SUI model according to the results of histological examination and urodynamic testing. Therefore, magnetically guided targeting strategy might be a potential therapy method for treatment of SUI. Copyright © 2020. Published by Elsevier Inc.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 2 区 纳米科技 2 区 医学:研究与实验
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 医学:研究与实验 3 区 纳米科技
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出版当年[2020]版:
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q2 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版:
Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 NANOSCIENCE & NANOTECHNOLOGY

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第一作者机构: [1]Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, 200233, Shanghai, China
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通讯机构: [6]Department of Pharmacy, Taizhou Central Hospital, 318000, Zhejiang, China [7]Institute for Intestinal Diseases, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 200072, Shanghai, China
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