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Exosomes from adipose-derived stem cells and application to skin wound healing.

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资源类型：
Pubmed体系：
作者：
An Yang[1,*1] * ; Lin Shuyan[2] * ; Tan Xiaojie[1] * ; Zhu Shiou[3] ; Nie Fangfei[1] ; Zhen Yonghuan[1] ; Gu Luosha[1] ; Zhang Chunlei[4] ; Wang Baicheng[1] ; Wei Wei[5] ; Li Dong[1,*1] ; Wu Junhao[2,*2] ;
机构： [1]Department of Plastic Surgery, Peking University Third Hospital, Beijing, China [2]Hearing Ctr, Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China [3]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China [4]Institute of Systems Biomedicine, Peking University, Beijing, China [5]Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China
出处：
DOI： 10.1111/cpr.12993
ISSN：

摘要：
Skin wound healing is an intractable problem that represents an urgent clinical need. To solve this problem, a large number of studies have focused on the use of exosomes (EXOs) derived from adipose-derived stem cells (ADSCs). This review describes the mechanisms whereby ADSCs-EXOs regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immune responses and inflammation. They also promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling which inhibits scar hyperplasia. Compared with ADSCs therapeutics, ADSCs-EXOs have highly stability and are easily stored. Additionally, they are not rejected by the immune system and have a homing effect and their dosage can be easily controlled. ADSCs-EXOs can improve fat grafting and promote wound healing in patients with diabetes mellitus. They can also act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair. Overall, ADSCs-EXOs have the potential to be used in the clinic to promote wound healing. © 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

基金：
This work was supported by the National Nature Science Foundation of China (No. 81873939), the Scientific Research Staring Foundation for the Returned Overseas Chinese Scholars, Peking University Third Hospital (No. BYSYLXHG2019001), and Key Clinical Projects of Peking University Third Hospital (No. BYSYZD2019013).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
第一作者：
第一作者机构： [1]Department of Plastic Surgery, Peking University Third Hospital, Beijing, China [*1]Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Plastic Surgery, Peking University Third Hospital, Beijing, China [2]Hearing Ctr, Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China [*1]Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China. [*2], Hearing Ctr, Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
推荐引用方式(GB/T 7714)：
An Yang,Lin Shuyan,Tan Xiaojie,et al.Exosomes from adipose-derived stem cells and application to skin wound healing.[J].Cell proliferation.2021,54(3):e12993.doi:10.1111/cpr.12993.
APA：
An Yang,Lin Shuyan,Tan Xiaojie,Zhu Shiou,Nie Fangfei...&Wu Junhao.(2021).Exosomes from adipose-derived stem cells and application to skin wound healing..Cell proliferation,54,(3)
MLA：
An Yang,et al."Exosomes from adipose-derived stem cells and application to skin wound healing.".Cell proliferation 54..3(2021):e12993

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