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Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence.

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机构： [a]Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China [b]Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China [c]Department of General Educational Development, Faculty of Science and Information Technology, Daffodil International University, Dhaka 1207, Bangladesh [d]Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine Winston-Salem, NC 27157, USA [e]Department of Urology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China

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关键词： Stress urinary incontinence Extracellular matrix Decellularization Adipose-derived stem cells Tissue engineering

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Injection of urethral bulking agents is a low-risk, minimally invasive surgical procedure to treat stress urinary incontinence (SUI). In this study, we developed a promising injectable bulking agent comprising extracellular matrix fragments of adipose-derived stem cell sheets (ADSC ECM) and investigated its effectiveness in urethral bulking therapy. The structural integrity and proteins of ADSC sheet ECM were well retained in decellularized ADSC ECM fragments. To locate transplanted ADSC ECM fragments, they were labeled with ultrasmall super-paramagnetic iron oxide nanoparticles, which enabled in vivo monitoring after implantation in a SUI rat model for up to 4 weeks. When ADSC ECM fragments were injected into the rat urethra, they became fully integrated with the surrounding tissue within 1 week. Four weeks after transplantation, host cells had regenerated within the ADSC ECM fragment injection area. Moreover, new smooth muscle tissue had formed around the ADSC ECM fragments, as confirmed by positive staining of myosin. These results indicate that injection of ECM fragments may be a promising minimally invasive approach for treating SUI. Copyright © 2020. Published by Elsevier Ltd.

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出版当年[2020]版：

大类 | 1 区

工程技术

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

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出版当年[2020]版：

Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 ENGINEERING, BIOMEDICAL

最新[2023]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 9.4 最新[2023版] 9.9 最新五年平均 8.947 出版当年[2020版] 9 出版当年五年平均 7.242 出版前一年[2019版] 10.633 出版后一年[2021版]

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第一作者机构： [a]Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China

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Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence.

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