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Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence.

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收录情况： ◇ SCIE

作者：
Ying Wang[a] ; Meng Duan[b] ; Mahbubur Rahman[c] ; Ming Yang[a] ; Weixin Zhao[d] ; Shukui Zhou[e] ; Guo Gao[b] ; Qiang Fu[a] ;
机构： [a]Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China [b]Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China [c]Department of General Educational Development, Faculty of Science and Information Technology, Daffodil International University, Dhaka 1207, Bangladesh [d]Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine Winston-Salem, NC 27157, USA [e]Department of Urology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China
出处：
DOI： 10.1016/j.actbio.2020.09.049
ISSN：

关键词： Stress urinary incontinence Extracellular matrix Decellularization Adipose-derived stem cells Tissue engineering

摘要：
Injection of urethral bulking agents is a low-risk, minimally invasive surgical procedure to treat stress urinary incontinence (SUI). In this study, we developed a promising injectable bulking agent comprising extracellular matrix fragments of adipose-derived stem cell sheets (ADSC ECM) and investigated its effectiveness in urethral bulking therapy. The structural integrity and proteins of ADSC sheet ECM were well retained in decellularized ADSC ECM fragments. To locate transplanted ADSC ECM fragments, they were labeled with ultrasmall super-paramagnetic iron oxide nanoparticles, which enabled in vivo monitoring after implantation in a SUI rat model for up to 4 weeks. When ADSC ECM fragments were injected into the rat urethra, they became fully integrated with the surrounding tissue within 1 week. Four weeks after transplantation, host cells had regenerated within the ADSC ECM fragment injection area. Moreover, new smooth muscle tissue had formed around the ADSC ECM fragments, as confirmed by positive staining of myosin. These results indicate that injection of ECM fragments may be a promising minimally invasive approach for treating SUI. Copyright © 2020. Published by Elsevier Ltd.

基金：
This research was supported by the National Natural Sci- ence Foundation of China (No. 81270780 , 81800593 , 81470917 and 81671737 ), the Natural Science Foundation of Shanghai (No. 20ZR1442100 ), the Doctorate Innovation Fund of Shanghai Jiao Tong University School of Medicine (No. BXJ201943 ) and the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2019QNB31 ), Collaborative Innovation Program on Translational Medicine of Shanghai Jiao Tong University School of Medicine (No. TM201818 ), Program for Outstanding Medical Academic Leader of Shanghai, and incubation project of outstanding Young Scien- tist Fund of Sichuan Province (No. 2019JDJQ0039 ), the Key Re- search Foundation of Sichuan provincial health commission (No. 19ZD015 ), “the Belt and Road”young scientist exchange pro- gram of the Science and Technology Commission of Shanghai (No. 18410741600 ). The authors gratefully acknowledge the Shanghai Outstanding Academic Leaders Plan (No. 17XD1403100 )

基金编号： No. 81270780 , 81800593 , 81470917 and 81671737

语种：
外文
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 工程技术
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2020]版：
Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 ENGINEERING, BIOMEDICAL
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [a]Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ying Wang,Meng Duan,Mahbubur Rahman,et al.Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence.[J].ACTA BIOMATERIALIA.2020,117:156-166.doi:10.1016/j.actbio.2020.09.049.
APA：
Ying Wang,Meng Duan,Mahbubur Rahman,Ming Yang,Weixin Zhao...&Qiang Fu.(2020).Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence..ACTA BIOMATERIALIA,117,
MLA：
Ying Wang,et al."Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence.".ACTA BIOMATERIALIA 117.(2020):156-166

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