机构：[1]Institute of Digestive Surgery and Department of Colorectal Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院[2]Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院
In this paper, we investigated the effect of the traditional Chinese medicine Chaiqin Chengqi Decoction (CQCQD) on serum cytokines in acute pancreatitis (AP) patients.
Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment. Control samples were collected from 20 healthy individuals. Serum proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist (IL-1ra) were examined using the Luminex 100 system.
Within the first 48 h of AP onset, IL-6 and IL-1ra levels in severe AP (SAP) patients were significantly higher than those in mild AP (MAP) patients, but IL-10 levels in SAP patients were significantly lower than those in MAP patients. Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment (P<0.05), especially in SAP patients (n=25 of 36, P<0.05). The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment (P<0.05).
CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.
基金：
National Natural Science Foundation of
China (Nos. 30830100 and 30972924) and the Scientific Research
Foundation for the Returned Overseas Chinese Scholars, State Education
Ministry (No. 20101174-4-2)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2011]版：
大类|4 区生物
小类|4 区生化与分子生物学4 区生物工程与应用微生物
最新[2023]版：
大类|3 区生物学
小类|3 区生物工程与应用微生物4 区生化与分子生物学4 区医学：研究与实验
第一作者：
第一作者机构：[1]Institute of Digestive Surgery and Department of Colorectal Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Ling,Li Yuan,Ma Qin,et al.Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis.[J].Journal of Zhejiang University Science B：Biomedicine & Biotechnology.2011,12(12):1034-40.doi:10.1631/jzus.B1000406.
APA：
Wang Ling,Li Yuan,Ma Qin,Liu Yong,Rui Yuan-yi...&Zhou Zong-guang.(2011).Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis..Journal of Zhejiang University Science B：Biomedicine & Biotechnology,12,(12)
MLA：
Wang Ling,et al."Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis.".Journal of Zhejiang University Science B：Biomedicine & Biotechnology 12..12(2011):1034-40
