机构：[1]Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, Hubei 430022, P.R. China华中科技大学同济医学院附属协和医院[2]Microarray Core Facility, Dana-Farber Cancer Institute, Boston, MA 02138, USA[3]Organ Transplantation Center, Hospital of the University of Electronic Science and Technology of China andSichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China四川省人民医院
In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were enrolled in this retrospective study. Fifty-nine patients in the HES group received 6% HES 130/0.4 combined with crystalloid solution for fluid resuscitation (HES group). In the control group, 61 patients received only crystalloid solution after admission. Interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha levels in serum were measured on days 1, 2, 4 and 8. The peripheral blood CD4(+)CD8(+) T lymphocyte rates, serum BUN and Cr values were also measured on days 1, 4 and 8. Patients with FB(-) rates were recorded from day 1 to 8. Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-alpha in the HES group compared with the control group. The difference in curve's risk ratio was not significant for IL-6, CD4(+)CD8(+) T lymphocyte rate, BUN and Cr values (P>0.05). In the HES group, we detected a significantly higher rate of patients with FB(-) from day 4 to 8 (P<0.05). Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient's immune status as well as renal function during the early phase of SAP.
第一作者机构：[1]Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, Hubei 430022, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, Hubei 430022, P.R. China[3]Organ Transplantation Center, Hospital of the University of Electronic Science and Technology of China andSichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China[*1]Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei 430022, P.R. China[*2]Organ Transplantation Center, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 West Second Section First Ring Road, Chengdu, Sichuan 610072, P.R. China
推荐引用方式(GB/T 7714)：
Chen Qi-Jun,Yang Zhi-Yong,Wang Chun-You,et al.Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2016,12(5):3213-3220.doi:10.3892/etm.2016.3744.
APA：
Chen, Qi-Jun,Yang, Zhi-Yong,Wang, Chun-You,Dong, Li-Ming,Zhang, Yu-Shun...&Yang, Chong.(2016).Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study.EXPERIMENTAL AND THERAPEUTIC MEDICINE,12,(5)
MLA：
Chen, Qi-Jun,et al."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study".EXPERIMENTAL AND THERAPEUTIC MEDICINE 12..5(2016):3213-3220
