机构：[1]West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[2]Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610213, China.四川大学华西医院
Sphingosine-1-phosphate (S1P) is a sphingolipid metabolic product produced via the phosphorylation of sphingosine by sphingosine kinases (SPHKs), serving as a powerful modulator of various cellular processes through its interaction with S1P receptors (S1PRs). Currently, this incompletely understood mechanism in pancreatic diseases including pancreatitis and pancreatic cancer, largely limits therapeutic options for these disorders. Recent evidence indicates that S1P significantly contributes to pancreatic diseases by modulating inflammation, promoting pyroptosis in pancreatic acinar cells, regulating the activation of pancreatic stellate cells, and affecting organelle functions in pancreatic cancer cells. Nevertheless, no review has encapsulated these advancements. Thus, this review compiles information about the involvement of S1P signaling in exocrine pancreatic disorders, including acute pancreatitis, chronic pancreatitis, and pancreatic cancer, as well as prospective treatment strategies to target S1P signaling for these conditions. The insights presented here possess the potential to offer valuable guidance for the implementation of therapies targeting S1P signaling in various pancreatic diseases.
基金：
The research was funded by the National Natural Science Foundation of China (No. 82104598
to C.H.), the Key Research and Development Program of Sichuan Province (No. 2024YFFK0153 to C.H.),
and the Natural Science Foundation Youth Fund of Sichuan Province (No. 2023NSFSC1755 to D.D.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|2 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.[2]Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610213, China.
共同第一作者：
通讯作者：
通讯机构：[1]West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.[2]Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610213, China.
推荐引用方式(GB/T 7714)：
Fu Fei,Li Wanmeng,Zheng Xiaoyin,et al.Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases[J].International Journal Of Molecular Sciences.2024,25(21):doi:10.3390/ijms252111474.
APA：
Fu Fei,Li Wanmeng,Zheng Xiaoyin,Wu Yaling,Du Dan&Han Chenxia.(2024).Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases.International Journal Of Molecular Sciences,25,(21)
MLA：
Fu Fei,et al."Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases".International Journal Of Molecular Sciences 25..21(2024)
