机构：[1]Department of Laboratory Medicine, the People’s Hospital of Leshan, Leshan, Sichuan, China [2]epartment of Cardiothoracic Surgery, the People’s Hospital of Leshan, Leshan, Sichuan, China [3]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China
Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, and evaluate its effect on BC risk. This hospital-based case-control study comprised 228 patients with histologically confirmed BC and 251 healthy controls. The let-7a KRAS rs712 polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism. We observed no statistically significant association between BC risk and the let-7a KRAS rs712 polymorphism (GT vs GG, OR = 0.98, 95%CI = 0.66-1.46; TT vs GG, OR = 0.78, 95%CI = 0.28-2.21). However, the rs712 polymorphism was significantly associated with the N status of BC patients (GG vs GT/TT, OR = 0.52, 95%CI = 0.30- 0.92; G allele vs T allele, OR = 0.60, 95%CI = 0.37-0.97). We found no association between the let-7 rs712 polymorphism and BC risk. However, the let-7 rs712 G/T polymorphism was discovered to play a potential role in BC tumor metastasis; therefore, it may be employed as a new biomarker or therapy targeted towards resistant tumor metastasis.
基金：
the Natural Science Foundation of the Science and Technology Department of Leshan city (#13SZD143).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区生物
小类|4 区生化与分子生物学4 区遗传学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Laboratory Medicine, the People’s Hospital of Leshan, Leshan, Sichuan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Huang X,Yang Y,Guo Y,et al.Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer.[J].Genetics and molecular research : GMR.2015,14(4):16913-20.doi:10.4238/2015.December.14.19.
APA：
Huang X,Yang Y,Guo Y,Cao Z L,Cui Z W...&Gao L B.(2015).Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer..Genetics and molecular research : GMR,14,(4)
MLA：
Huang X,et al."Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer.".Genetics and molecular research : GMR 14..4(2015):16913-20
