机构：[1]Department of Thyriod SurgeryWest China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Sichuan Province, China[2]Department of Pancreatic SurgeryWest China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Sichuan Province, China[3]Department of Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Sichuan Province, China
The aim of this study was to investigate the association between 2 polymorphisms (ie, rs10877887 and rs13293512) in the promoter regions of let-7 and the risk of papillary thyroid carcinoma (PTC).A case-control study of 618 PTC patients and 562 controls was conducted. The rs10877887 polymorphism was genotyped by using polymerase chain reaction-restriction fragment length polymorphism and the rs13293512 polymorphism was genotyped by using a TaqMan Genotyping Assay. The results were confirmed by DNA sequencing.The rs10877887 polymorphism had reduced risks of PTC in heterozygous comparison, dominant model, and overdominant model (TC vs TT: adjusted odds ratio [OR] = 0.73, 95% confidence interval [95% CI] = 0.58-0.94, P = 0.01; TC/CC vs TT: adjusted OR = 0.79, 95% CI = 0.63-1.00, P = 0.047; TC vs TT/CC: adjusted OR = 0.73, 95% CI = 0.57-0.92, P = 0.007, respectively). Stratified analyses showed that PTC patients carrying the rs10877887 CC genotype were more likely to have multiple tumors (adjusted OR = 1.71, 95% CI = 1.03-2.86, P = 0.04), and PTC patients carrying the rs13293512 TC + CC or CC were more likely to develop N0 status (TC/CC vs TT: adjusted OR = 0.64, 95% CI = 0.43-0.94, P = 0.02; CC vs
adjusted OR = 0.50, 95% CI = 0.33-0.77, P = 0.001, respectively).Our study suggests that the rs10877887 polymorphism may be associated with the risk of PTC and the rs13293512 polymorphism may correlate to lymph node metastasis in PTC.
基金：
the Special Research Foundation of
Doctoral Priority to the Development of Field Project (No.
20110181130013), National Natural Science Foundation of China
(No. 81302149), Distinguished Young Scientist of Sichuan University
(No. 2013SCU04A38), the Science & Technology Pillar Program of
Sichuan Province (No. 2014SZ0001), and the Ph.D. Programs Foundation
of Ministry of Education of China (No. 20130181120011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|2 区医学
小类|2 区医学：内科
最新[2023]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[1]Department of Thyriod SurgeryWest China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Sichuan Province, China
通讯作者：
通讯机构：[1]Department of Thyriod SurgeryWest China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Sichuan Province, China[*1]Sichuan University, Chengdu 610041, Sichuan Province, China
推荐引用方式(GB/T 7714)：
Wang Yichao,Wei Tao,Xiong Junjie,et al.Association Between Genetic Polymorphisms in the Promoter Regions of Let-7 and Risk of Papillary Thyroid Carcinoma: A Case-Control Study.[J].Medicine.2015,94(43):e1879.doi:10.1097/MD.0000000000001879.
APA：
Wang Yichao,Wei Tao,Xiong Junjie,Chen Peng,Wang Xunli...&Zhu Jingqiang.(2015).Association Between Genetic Polymorphisms in the Promoter Regions of Let-7 and Risk of Papillary Thyroid Carcinoma: A Case-Control Study..Medicine,94,(43)
MLA：
Wang Yichao,et al."Association Between Genetic Polymorphisms in the Promoter Regions of Let-7 and Risk of Papillary Thyroid Carcinoma: A Case-Control Study.".Medicine 94..43(2015):e1879
