Objective To determine the associations between the polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers. Methods The allele and genotype frequencies of N372H in BRCA2 gene and 135G/C in RAD51 gene were analyzed with denaturing high performance liquid chromatography (DHPLC) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 71 women with breast cancers and 85 normal women. Results The women with breast cancers had higher frequencies of genotype HH of the N372H locus in BRCA2 gene than the normal women. No statistical difference in the polymorphic distribution of 135G/C in RAD51 gene was observed between the two groups of women. Conclusion The genotype HH of the N372H locus in BRCA2 is associated with breast cancers, which might be a genetic risk factor for breast cancers in Chinese populations.
语种：
中文
第一作者：
第一作者机构：[1]Department of Mastologic Surgery, Sichuan Cancer Hospital, Sichuan Province, Chengdu 610041, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu R,Wei Y,Jiang W.-J,等.Association of polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers[J].Journal of Sichuan University (Medical Science Edition).2008,39(6):
