机构：[1]Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.[2]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism. The ins/ins (ttca/ttca) genotype was significantly associated with a decreased risk of BC compared with the del/del (-/-) genotype (OR = 0.48, 95% CI = 0.27-0.85). Moreover, the ins (ttca) allele distribution between cases and controls was significantly different from the del (-) allele distribution (OR = 0.74, 95% CI = 0.57-0.96). Thus, the rs3783553 polymorphism is associated with a decreased incidence of breast cancer.
基金：
Research supported by the Natural Science Foundation of the Science and Technology
Department of Leshan city (#13SZD143)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区生物
小类|4 区生化与分子生物学4 区遗传学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Laboratory Medicine, the People's Hospital of Leshan, Leshan, Sichuan, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Huang X,Yang Y,Cui Z W,et al.A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.[J].Genetics and molecular research : GMR.2016,15(1):doi:10.4238/gmr.15017486.
APA：
Huang X,Yang Y,Cui Z W,Wang J&Gao L B.(2016).A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer..Genetics and molecular research : GMR,15,(1)
MLA：
Huang X,et al."A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.".Genetics and molecular research : GMR 15..1(2016)
