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Insertion/deletion polymorphism in IL1A 3'-UTR is associated with susceptibility to endometrial cancer in Chinese Han women.

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机构: [1]Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, China. [2]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China. [3]Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China.
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The aim of this study was to investigate whether a functional insertion/deletion polymorphism (rs3783553) located in the 3'-untranslated regions of interleukin-1 A is associated with susceptibility to endometrial cancer (EC) in Chinese Han women. A total of 272 patients and 294 age-matched healthy controls were included in the study. The genotype of the rs3783553 polymorphism was determined by polymerase chain reaction polyacrylamide gel electrophoresis. Our results showed that a significantly reduced risk of EC was found to be associated with the II (insertion/insertion) genotype compared with DD (deletion/deletion) only (P = 0.037, odds ratio = 0.56, 95% confidence interval = 0.32-0.97) as well as compared with the DD + DI (deletion/insertion) genotype (P = 0.032, odds ratio = 0.57, 95% confidence interval = 0.34-0.96) in the recessive model. No significant association was detected between certain clinical features of EC patients and genotype of rs3783553. This study demonstrates that the rs3783553 polymorphism may be involved in susceptibility to EC. The II genotype seems to be a protective factor for EC in Chinese Han women. © 2016 Japan Society of Obstetrics and Gynecology.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 妇产科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 妇产科学
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第一作者机构: [1]Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, China.
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通讯机构: [1]Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, China. [*1]Department of Obstetrics and Gynecology,West China Second Hospital, Sichuan University, Number 20, 3rd Section, South Renmin Road, Chengdu, Sichuan 610041, China
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